Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States
Satellite imagery characterizes local animal reservoir populations of Sin Nombre virus in the southwestern United States
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DOI：
10.1073/pnas.252617999
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发表时间：
2002-12-24
影响因子：
11.1
通讯作者：
Mills, JN
中科院分区：
文献类型：
--
作者：
Glass, GE;Yates, TL;Mills, JN
研究了根据卫星图像估计的汉他病毒肺综合征（HIPS）风险与当地啮齿动物种群之间的关系。在啮齿动物采样前预测的HIPS风险与Sin Nombre病毒（SNV）的宿主Peromyscus maniculatus的丰度高度相关。Maniculatus在高风险地区很常见，高风险地区的人群倾向于成年男性，这是最常感染SNV的亚类。在厄尔尼诺南方涛动（ENSO）之后的一年，只有在高风险地区才增加了对P. maniculatus的捕获。在1998年期间，少数地点有感染的小鼠，但到1999年，18/20的高风险地点含有感染的小鼠，粗患病率为30.8%。低风险场所中仅有1/18的场所存在感染鼠，感染率较低（8.3%）。卫星图像确定了与SNV在水库人群中传播相关的环境特征，但SNV达到高流行率至少需要2年的高风险条件。具有持续高风险环境条件的地区可作为SNV在当地小鼠种群中生存的避难所。
The relationship between the risk of hantaviral pulmonary syndrome (HIPS), as estimated from satellite imagery, and local rodent populations was examined. HIPS risk, predicted before rodent sampling, was highly associated with the abundance of Peromyscus maniculatus, the reservoir of Sin Nombre virus (SNV). P. maniculatus were common in high-risk sites, and populations in high-risk areas were skewed toward adult males, the subclass most frequently infected with SNV. In the year after an El Nino Southern Oscillation (ENSO), captures of P. maniculatus increased only in high-risk areas. During 1998, few sites had infected mice, but by 1999, 18/20 of the high-risk sites contained infected mice and the crude prevalence was 30.8%. Only 1/18 of the low-risk sites contained infected rodents, and the prevalence of infection was lower (8.3%). Satellite imagery identified environmental features associated with SNV transmission within its reservoir population, but at least 2 years of high-risk conditions were needed for SNV to reach high prevalence. Areas with persistently high-risk environmental conditions may serve as refugia for the survival of SNV in local mouse populations.