Increased catecholamines and heart rate in children with low birth weight:: perinatal contributions to sympathoadrenal overactivity
Increased catecholamines and heart rate in children with low birth weight:: perinatal contributions to sympathoadrenal overactivity
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DOI：
10.1111/j.1365-2796.2007.01776.x
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发表时间：
2007-05-01
影响因子：
11.1
通讯作者：
Vanpee, M.
中科院分区：
文献类型：
--
作者：
Johansson, S.;Norman, M.;Vanpee, M.
背景：低出生体重与心血管疾病有关。其潜在机制尚不清楚。我们假设围产期应激改变了心血管系统的自主调节。本研究测定了105例低出生体重儿的儿茶酚胺、心率和血压（平均年龄9.6岁）;正常出生体重足月出生（对照组，n = 37）、足月出生但小于胎龄（SGA，n = 29）和早产（Preterm，n = 39）。测定尿中多巴胺、肾上腺素和去甲肾上腺素。HR和BP测量休息时，在直立测试和数学精神stresstest.Results：早产儿和SGA组的儿童排出较高水平的儿茶酚胺相比，与对照组。与对照组（70 [9]和75 [9]）相比，早产儿（静息时76 [9]和精神应激后82 [12] min（-1））和SGA（79 [8]和82 [10]）在静息时和精神应激后的HR（平均[SD]值）较高。心率与尿儿茶酚胺呈显著正相关（r = 0.24-0.27，P < 0.05）。血压测量在休息时，在直立测试和精神stress.Conclusion：早产和胎儿生长受限后，groups. Conclusion没有显着差异与增加交感肾上腺活动在儿童时期，所示的压力引起的增加，HR和尿中的儿茶酚胺。这些发现表明，这些儿童的心血管控制是不同的程序，成年后患高血压的风险可能更高。
Background: Low birth weight is associated with cardiovascular disease. The underlying mechanisms are unknown. We hypothesized that perinatal stress alters autonomic regulation of the cardiovascular system. In this study, catecholamines, heart rate (HR) and blood pressure (BP) were measured in healthy children with low birth weight.Methods: This clinical study included 105 children (mean age 9.6 years) in three groups; born at term with normal birth weight (controls, n = 37), born at term but small for gestational age (SGA, n = 29) and born preterm (Preterm, n = 39). Dopamine, adrenaline and noradrenaline were determined in urine. HR and BP were measured at rest, during an orthostatic test and after a mathematical mental stress test.Results: Children in the Preterm and SGA groups excreted higher levels of catecholamines when compared with controls. HR (mean [SD] values) were higher at rest and after mental stress in Preterm (at rest 76 [9] and after mental stress 82 [12] min(-1)) and in SGA (79 [8] and 82 [10]) when compared with controls (70 [9] and 75 [9]). HR correlated with urinary catecholamines (r = 0.24-0.27, P < 0.05). Blood pressures measured at rest, during orthostatic testing and after mental stress did not differ between the groups.Conclusion: Preterm birth and fetal growth restriction are associated with increased sympathoadrenal activity in childhood, as indicated by stress-induced increases in HR and urinary catecholamines. These findings suggest that the cardiovascular control is differently programmed in these children with possibly higher risk of developing hypertension in adulthood.