Increased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegaly
Increased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegaly
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DOI：
10.1111/j.1365-2265.2009.03685.x
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发表时间：
2010-05-01
影响因子：
3.2
通讯作者：
Brites, F.
中科院分区：
文献类型：
--
作者：
Boero, L.;Cuniberti, L.;Brites, F.
活动性肢端肥大症与心血管原因导致的死亡率增加有关.几项研究表明，与生长激素过量相关的致动脉粥样硬化危险因素和炎症和动脉粥样硬化的生物标志物增加。本研究的目的是评估肢端肥大症患者氧化低密度脂蛋白（oxLDL）水平和LDL氧化修饰的一些调节剂。设计开放横向研究。研究了15例活动性肢端肥大症患者和15例对照者。测量我们评估了oxLDL、硫代巴比妥酸反应物质（TBARS）、铜蓝蛋白、胆红素、尿酸和总反应性抗氧化潜力的水平，以及铜蓝蛋白、髓过氧化物酶、超氧化物歧化酶、对氧磷酶1和血小板活化因子乙酰水解酶的活性。将体重指数作为协变量或固定变量进行统计学分析。结果肢端肥大症患者oxLDL水平显著高于正常人（120 +/- 19 vs. 86 +/- 20 U/l，P < 0中心点001）和内皮素与健康对照相比，TBARS浓度具有增加的血浆铜蓝蛋白活性（P <0，中心点05）、增加的血浆铜蓝蛋白活性（P < 0，中心点01）和朝向更高值的趋势（P = 0，中心点07）。OxLDL与GH、IGF-I及其结合蛋白3呈正相关（r = 0中心点63，P < 0中心点001; r = 0中心点53，P < 0中心点01; r = 0中心点56，P < 0中心点01）。OxLDL与内皮素-1（r = 0中心点53，P < 0中心点01）和铜蓝蛋白活性（r = 0中心点43，P < 0中心点05）直接相关。其他参数的评价是相似的，在这两个group.ConclusionsThe血浆oxLDL水平的增加，斑块形成的直接标志物，可以构成动脉粥样硬化和活动性肢端肥大症之间的联系。LDL氧化不是抗氧化防御减弱的结果，而是促氧化因子如铜蓝蛋白增强的结果。
P>ObjectiveActive acromegaly is associated with increased mortality from cardiovascular causes. Several studies have shown increased atherogenic risk factors and biomarkers of inflammation and atherosclerosis in association with growth hormone excess. The aim of this study was to evaluate oxidized low density lipoprotein (oxLDL) levels and some modulators of LDL oxidative modification in patients with acromegaly.DesignOpen transversal study.PatientsFifteen patients with active acromegaly and 15 controls were studied.MeasurementsWe evaluated the levels of oxLDL, thiobarbituric acid reactive substances (TBARS), ceruloplasmin, bilirubin, uric acid and total reactive antioxidant potential, and the activities of ceruloplasmin, myeloperoxidase, superoxide distmutase, paraoxonase 1, and platelet activating factor acethylhydrolase. Statistical analysis was performed including body mass index as a covariate or as a fixed variable.ResultsPatients with acromegaly showed significantly higher levels of oxLDL (120 +/- 19 vs. 86 +/- 20 U/l, P < 0 center dot 001) and endothelin (P < 0 center dot 05), increased ceruloplasmin activity (P < 0 center dot 01) and a trend towards higher values in TBARS concentration (P = 0 center dot 07) in comparison to healthy controls. OxLDL was positively associated with GH, IGF-I and its binding protein 3 (r = 0 center dot 63, P < 0 center dot 001; r = 0 center dot 53, P < 0 center dot 01; and r = 0 center dot 56, P < 0 center dot 01; respectively). OxLDL showed direct associations with endothelin-1 (r = 0 center dot 53, P < 0 center dot 01) and ceruloplasmin activity (r = 0 center dot 43, P < 0 center dot 05). The other parameters evaluated were similar in both groups.ConclusionsThe increase in plasma oxLDL levels, a direct marker of the plaque formation, could constitute a link between atherosclerosis and active acromegaly. LDL oxidation would not be the consequence of diminished antioxidant defences, but of an enhancement in prooxidant factors like ceruloplasmin.