Extraction of prefronto-amygdalar pathways by combining probability maps
Extraction of prefronto-amygdalar pathways by combining probability maps
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DOI：
10.1016/j.pscychresns.2009.05.001
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发表时间：
2009-12-30
影响因子：
2.3
通讯作者：
Saur, Dorothee
中科院分区：
文献类型：
--
作者：
Bracht, Tobias;Tuescher, Oliver;Saur, Dorothee
许多最近的研究报告改变功能连接额边缘电路在广泛的神经精神疾病。然而，功能连接必须依赖于结构连接。在这项研究中，我们采用了一种新的概率纤维跟踪方法来评估杏仁核和不同的前额叶脑区在体内的结构连接。20例健康受试者进行了弥散张量成像。从杏仁核和不同的前额叶脑区开始追踪概率纤维。使用概率图的扩展乘法组合产生的概率图，以识别连接这些结构的最可能的解剖路径。我们发现一条腹侧通路穿过钩束，连接杏仁核和内侧及外侧眶额皮质。除了这个腹侧通路，我们还描绘了不同的背侧通路（内侧和外侧），它们将杏仁核与前扣带皮层和背外侧前额叶皮层连接起来。背内侧通路通过丘脑下脚，而背外侧通路通过外囊。我们相信，我们的方法提供了一个有前途的工具，以评估与神经精神疾病患者的特定结构连接的完整性。(C)2009爱思唯尔爱尔兰有限公司保留所有权利。
Many recent studies reported altered functional connectivity within the frontolimbic circuitry in a wide range of neuropsychiatric disorders. However, functional connectivity must rely on structural connections. In this study we applied a novel probabilistic fiber tracking method to assess the structural connectivity between the amygdala and different prefrontal brain regions in vivo. Twenty healthy subjects were investigated with diffusion tensor imaging. Probabilistic fiber tracking was started from the amygdala and different prefrontal brain regions. Resulting probability maps were combined using an extended multiplication of probabilistic maps to identify the most probable anatomical pathways connecting these structures. We found one ventral pathway through the uncinate fascicle, connecting the amygdala and the medial and lateral orbitofrontal cortices. In addition to this ventral pathway, we depicted distinct dorsal pathways (medial and lateral), which connect the amygdala with the anterior cingulate cortex and the dorsolateral prefrontal cortex. The dorso-medial pathway proceeds through the inferior thalamic peduncle, while the dorsolateral pathway travels through the external capsule. We believe that our approach provides a promising tool to assess the integrity of specific structural connections in patients with neuropsychiatric disorders. (C) 2009 Elsevier Ireland Ltd. All rights reserved.