ELEVATED CIRCULATING TUMOR-NECROSIS-FACTOR LEVELS IN ALZHEIMERS-DISEASE
ELEVATED CIRCULATING TUMOR-NECROSIS-FACTOR LEVELS IN ALZHEIMERS-DISEASE
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DOI：
10.1016/0304-3940(91)90490-k
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发表时间：
1991-08-19
影响因子：
2.5
通讯作者：
WOLFKLEIN, G
中科院分区：
文献类型：
--
作者：
FILLIT, H;DING, W;WOLFKLEIN, G
最近的研究表明，阿尔茨海默病（AD）的局部炎症反应，包括小胶质细胞和细胞因子。 通过酶联免疫测定法和细胞毒性生物测定法测量AD患者和年龄匹配对照血清中细胞因子肿瘤坏死因子-α（TNF-alpha）的水平。 与对照组相比，AD血清中TNF水平显著升高。 升高的循环TNF可能源自AD中的局部CNS炎症反应，并且可能解释AD的一些全身性表现，例如体重减轻。 未来的研究可能会确定，在没有可能升高TNF的并发症的情况下，循环TNF可能是AD炎症活动的标志物。
Recent investigations have demonstrated a local inflammatory response in Alzheimer's disease (AD), including microglia and cytokines. Levels of the cytokine tumor necrosis factor-alpha (TNF-alpha) in sera from patients with AD and age-matched controls were measured by an enzyme-linked immunoassay and a cytotoxicity bioassay. Significantly elevated levels of TNF were found in AD sera compared to controls. Elevated circulating TNF may be derived from the local CNS inflammatory reaction in AD, and may account for some systemic manifestations of AD such as weight loss. Future studies may determine if, in the absence of complicating disorders which may elevate TNF, circulating TNF could be a marker of AD inflammatory activity.