Quantifying contributions of the cricopharyngeus to upper esophageal sphincter pressure changes by means of intramuscular electromyography and high-resolution manometry.
Quantifying contributions of the cricopharyngeus to upper esophageal sphincter pressure changes by means of intramuscular electromyography and high-resolution manometry.
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DOI：
10.1177/0003489414522975
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发表时间：
2014-03
期刊：
影响因子：
--
通讯作者：
McCulloch TM
中科院分区：
文献类型：
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作者：
Jones CA;Hammer MJ;Hoffman MR;McCulloch TM
我们试图确定环咽肌活动和食管上括约肌压力之间的关系是否可能以任务依赖的方式改变。我们假设，与吞咽或气道保护相关的更多自动化任务比与潮汐呼吸或发声相关的更多意志任务产生更强的关联。6名健康成人同时进行环咽肌肌电图和食管上括约肌高分辨率测压。计算相关系数来表征时间关联序列之间的关联。在吞咽和用力呼气时，环咽肌活动与食管上括约肌压力的关系最为密切（r分别为0.77和0.79,P < 0.01）。在吞咽和用力呼气时，这种关联也变化较小。这些发现表明，对于更自动化的任务来说，耦合性更强，而对于更意志化的、与声音相关的任务来说，耦合性更弱，灵活性更强。这些发现支持了中枢模式在呼吸和吞咽相关任务中的重要作用。
We sought to determine whether the association between cricopharyngeus muscle activity and upper esophageal sphincter pressure may change in a task-dependent fashion. We hypothesized that more automated tasks related to swallow or airway protection would yield a stronger association than would more volitional tasks related to tidal breathing or voice production. Six healthy adult subjects underwent simultaneous intramuscular electromyography of the cricopharyngeus muscle and high-resolution manometry of the upper esophageal sphincter. Correlation coefficients were calculated to characterize the association between the time-linked series. Cricopharyngeus muscle activity was most strongly associated with upper esophageal sphincter pressure during swallow and effortful exhalation tasks (r = 0.77 and 0.79, respectively; P < .01). The association was also less variable during swallow and effortful exhalation. These findings suggest a greater coupling for the more automatic tasks, and may suggest less coupling and more flexibility for the more volitional, voice-related tasks. These findings support the important role of central patterning for respiratory- and swallow-related tasks.