Diet, obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis.
Diet, obesity and hypertension: an hypothesis involving insulin, the sympathetic nervous system, and adaptive thermogenesis.
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DOI：
10.1093/oxfordjournals.qjmed.a068066
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发表时间：
1986-12
期刊：
影响因子：
--
通讯作者：
L. Landsberg
中科院分区：
文献类型：
--
作者：
L. Landsberg
肥胖和高血压的关联已得到广泛认可。尽管肥胖受试者患高血压的频率因研究人群的年龄、种族和性别以及“高血压”和“肥胖”的定义而异，但一些报告表明，多达 50% 至 60% 的超重人群患有高血压 [1, 2]。更重要的是，高血压可能是导致肥胖者心血管疾病增加的主要因素 [3, 4]。尽管临床问题很重要，但高血压与肥胖之间的关联的基本性质然而，最近的流行病学和生理学研究表明，胰岛素和交感神经系统可能参与其中，肥胖引起的高血压可能是建立能量平衡和限制体重增加的机制的不幸副产品。
The association of obesity and hypertension is well recognized. Although the frequency of hypertension in obese subjects varies depending upon the age, race, and sex of the population studied, as well as the definitions employed for 'hypertension' and 'obesity", several reports suggest that as many as 50 to 60 percent of overweight people have high blood pressure [1, 2]. Hypertension, more importantly, is probably the major factor accounting for increased cardiovascular disease in the obese [3, 4]. Despite the importance of the clinical problem, the fundamental nature of the association between obesity and hypertension has been obscure. Recent epidemiological and physiological studies, however, suggest that insulin and the sympathetic nervous system may be involved, and that the hypertension of obesity may be the unfortunate by-product of mechanisms that establish energy balance and limit weight gain.