AGING-ASSOCIATED INCREASE IN INTESTINAL-ABSORPTION OF MACROMOLECULES
AGING-ASSOCIATED INCREASE IN INTESTINAL-ABSORPTION OF MACROMOLECULES
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DOI：
10.1159/000212694
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发表时间：
1985-01-01
期刊：
影响因子：
3.5
通讯作者：
TARNAWSKI, H
中科院分区：
文献类型：
--
作者：
HOLLANDER, D;TARNAWSKI, H
研究了不同分子量聚乙二醇400（PEG 400）对老龄大鼠肠道通透性的影响。动物通过经口灌胃接受PEG 400推注，并收集尿液6 h以评估其吸收速率。通过气液色谱法定量显示，总尿排泄的PEG 400随着年龄的增长而增加。34周龄大鼠排泄了34.3%的给药剂量，而133周龄大鼠则排泄了43.6%的给药剂量。该效应在较高MW PEG的情况下更明显，因为随着老化，较低MW PEG 282的排泄减少10.5%，而PEG 634的排泄增加11.4%。肠道对较高分子量PEG物质的渗透性增加可能表明，对潜在有害环境物质吸收的肠道保护屏障在老龄动物中可能效率较低。如果在老年人中发现类似的发现，则可能表明肠腔吸收大抗原或致癌化合物的可能性增加。
The intestinal permeability of aging rats to various MW species of polyethylene glycol 400 (PEG 400) was studied. Animals received a bolus of PEG 400 by oral gavage and urine was collected for 6 h to assess its rate of absorption. Quantitation by gas liquid chromatography revealed that total urinary excretion of PEG 400 increased with aging. Thirty-four-week-old rats excreted 34.3% of the administrated dose while 43.6% was excreted in the urine by rats 133 wk of age. This effect was more pronounced with the higher MW PEG since excretion of the lower MW PEG 282 decreased by 10.5% while PEG 634 excretion increased by 11.4% with aging. The increased permeability of the intestinal tract to higher MW species of PEG may indicate that the intestinal protective barrier to the absorption of potentially harmful environmental substances may be less efficient in aging animals. If similar findings are found in aging humans, they may indicate increased potential for absorption of large antigenic or carcinogenic compounds from the intestinal lumen.