The roles of different microRNAs in the regulation of cholesterol in viral hepatitis.
The roles of different microRNAs in the regulation of cholesterol in viral hepatitis.
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DOI：
10.1186/s12964-023-01250-w
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发表时间：
2023-09-14
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胆固醇在稳定脂筏或膜筏中起重要作用，脂筏或膜筏是特定的细胞膜结构。胆固醇参与许多细胞过程，包括调节病毒进入宿主细胞。多种病毒已显示依赖胆固醇进行病毒进入和/或形态发生。研究表明，宿主脂质代谢的重编程与导致慢性肝炎的病毒进展为严重肝病的B型肝炎病毒（HBV）和丙型肝炎病毒（HCV）感染相关。此外，了解病毒与靶细胞相互作用的精确模式有助于了解病毒的发病机制，并有助于开发疫苗和治疗靶点。因此，降胆固醇治疗领域正在迅速发展，并有许多新的抗病毒靶点和药物。已经表明，microRNA（miRNAs）直接或间接靶向病毒基因组，阻止病毒复制。此外，最近已经显示miRNA是参与脂质代谢的基因的强转录后调节因子，特别是参与胆固醇稳态的基因。作为几种病毒感染中脂质稳态的重要调节因子，miRNAs最近被发现。此外，多项研究表明，在病毒感染期间，miRNA调节甲羟戊酸/胆固醇途径中的几种酶。由于胆固醇代谢对病毒性肝炎和其他病毒的生命周期至关重要，因此对miRNA调控的深入了解可能有助于开发新的抗HCV治疗方法。本文就miRNAs作为胆固醇调节剂对病毒性肝炎的作用机制进行综述。 视频摘要在线版本包含补充材料，可通过10. 1186/s12964-023-01250-w获取。
Cholesterol plays a significant role in stabilizing lipid or membrane rafts, which are specific cellular membrane structures. Cholesterol is involved in numerous cellular processes, including regulating virus entry into the host cell. Multiple viruses have been shown to rely on cholesterol for virus entry and/or morphogenesis. Research indicates that reprogramming of the host’s lipid metabolism is associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) infections in the progression to severe liver disease for viruses that cause chronic hepatitis. Moreover, knowing the precise mode of viral interaction with target cells sheds light on viral pathogenesis and aids in the development of vaccines and therapeutic targets. As a result, the area of cholesterol-lowering therapy is quickly evolving and has many novel antiviral targets and medications. It has been shown that microRNAs (miRNAs) either directly or indirectly target the viral genome, preventing viral replication. Moreover, miRNAs have recently been shown to be strong post-transcriptional regulators of the genes involved in lipid metabolism, particularly those involved in cholesterol homeostasis. As important regulators of lipid homeostasis in several viral infections, miRNAs have recently come to light. In addition, multiple studies demonstrated that during viral infection, miRNAs modulate several enzymes in the mevalonate/cholesterol pathway. As cholesterol metabolism is essential to the life cycle of viral hepatitis and other viruses, a sophisticated understanding of miRNA regulation may contribute to the development of a novel anti-HCV treatment. The mechanisms underlying the effectiveness of miRNAs as cholesterol regulators against viral hepatitis are explored in this review. Video Abstract The online version contains supplementary material available at 10.1186/s12964-023-01250-w.
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影响因子：
64.8
作者：
Cote, Marceline;Misasi, John;Ren, Tao;Bruchez, Anna;Lee, Kyungae;Filone, Claire Marie;Hensley, Lisa;Li, Qi;Ory, Daniel;Chandran, Kartik;Cunningham, James
通讯作者：
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DOI：
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发表时间：
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影响因子：
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