Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence.
Ethnic and gender differences in advanced glycation end products measured by skin auto-fluorescence.
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DOI：
10.4161/derm.26046
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发表时间：
2013-04-01
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影响因子：
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通讯作者：
Mook-Kanamori DO
中科院分区：
文献类型：
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作者：
Mook-Kanamori MJ;Selim MM;Takiddin AH;Al-Homsi H;Al-Mahmoud KA;Al-Obaidli A;Zirie MA;Rowe J;Gherbi WS;Chidiac OM;Kader SA;Al Muftah WA;McKeon C;Suhre K;Mook-Kanamori DO
背景 晚期糖基化终产物（AGEs）已被证明是高加索受试者心血管风险的预测因子。在这项研究中，我们检查现有的参考值是否适用于非高加索种族。此外，我们还评估了性别和吸烟是否会影响AGEs。方法采用皮肤自发荧光法（AF）测定AGEs。在卡塔尔糖尿病代谢组学研究（QMDiab）中，对200名阿拉伯人、99名南亚人、35名菲律宾人和14名其他/混合种族受试者进行了AF测量。采用多元线性回归分析和调整年龄和2型糖尿病，我们评估是否种族，性别和吸烟与AF。结果平均AF为2.27任意单位（Au）（SD：0.63）。阿拉伯人和菲律宾人的AF显著高于南亚人群（分别为0.25任意单位（Au）（95% CI：0.11 <$0.39），p = 0.001和0.34（95% CI：0.13 <$0.55），p = 0.001）。此外，女性的AF显著更高（0.41 Au（95% CI：0.29 ± 0.53），p < 0.001）。AF与吸烟相关（0.21 Au（95% CI：0.01 ~ 0.41），p = 0.04），并随吸烟包年数增加而增加（p = 0.02）。结论本研究建议，现有的参考值应考虑到种族，性别和吸烟。有必要在特定族裔中进行更大规模的研究，以建立针对族裔和性别的参考值。
Background Advanced glycation end products (AGEs) have been shown to be a predictor of cardiovascular risk in Caucasian subjects. In this study we examine whether the existing reference values are useable for non-Caucasian ethnicities. Furthermore, we assessed whether gender and smoking affect AGEs. Methods AGEs were determined by a non-invasive method of skin auto-fluorescence (AF). AF was measured in 200 Arabs, 99 South Asians, 35 Filipinos and 14 subjects of other/mixed ethnicity in the Qatar Metabolomics Study on Diabetes (QMDiab). Using multivariate linear regression analysis and adjusting for age and type 2 diabetes, we assessed whether ethnicity, gender and smoking were associated with AF. Results The mean AF was 2.27 arbitrary units (AU) (SD: 0.63). Arabs and Filipinos had a significant higher AF than the South Asian population (0.25 arbitrary units (AU) (95% CI: 0.11‒0.39), p = 0.001 and 0.34 (95% CI: 0.13‒0.55), p = 0.001 respectively). Also, AF was significantly higher in females (0.41 AU (95% CI: 0.29‒0.53), p < 0.001). AF associated with smoking (0.21 AU (95% CI: 0.01‒0.41), p = 0.04) and increased with the number of pack-years smoked (p = 0.02). Conclusions This study suggests that the existing reference values should take ethnicity, gender and smoking into account. Larger studies in specific ethnicities are necessary to create ethnic- and gender-specific reference values.