Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort
Common variants of the UMOD promoter associated with blood pressure in a community-based Chinese cohort
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中国社区队列中与血压相关的 UMOD 启动子常见变异
DOI：
10.1038/hr.2012.51
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发表时间：
2012-07-01
影响因子：
5.4
通讯作者：
Wang, Haiyan
中科院分区：
文献类型：
--
作者：
Han, Jia;Chen, Yuqing;Wang, Haiyan
高血压是慢性肾脏病的重要危险因素。肾脏反过来在血压（BP）的调节中起着重要作用。在全基因组关联研究的基础上，尿调蛋白（UMOD）启动子区域的单核苷酸多态性被认为影响肾钠重吸收和血压。在这项研究中，我们询问了UMOD基因的常见变异是否会影响基于社区的中国队列中的BP。我们在北京社区人群中筛选了UMOD基因座上的7个常见变异，包括1000名个体，其中48%为男性，平均年龄为63.7±9.0岁。采用酶联免疫吸附法测定尿UMOD浓度。然后，我们分析了UMOD的常见变异与BP的关联。UMOD启动子常见变异rs 13333226 G/A与舒张压（DBP）相关，G等位基因携带者DBP高于A/A纯合子（P= 0.035）。变异rs6497476 C/T预测DBP水平，C纯合子的DBP水平高于CT杂合子和T纯合子（P= 0.025）。尿UMOD排泄与尿钠排泄相关（R= 0.239，P= 0.656* 10− 13）。我们在一个以社区为基础的中国队列中确定了UMOD的常见变异与DBP水平相关。
Hypertension is an important risk factor for chronic kidney disease. The kidney, in turn, has an important role in the regulation of blood pressure (BP). On the basis of a genome-wide association study, single-nucleotide polymorphisms in the uromodulin (UMOD) promoter region had been considered to influence both renal sodium reabsorption and BP. In this study, we asked whether common variants across the UMOD gene influence BP in a community-based Chinese cohort. We screened seven common variants across the UMOD locus in a community-based population from Beijing, including 1000 individuals with 48% males and an average age of 63.7±9.0 years. The urinary UMOD concentration was measured by enzyme-linked immunosorbent assay. We then analyzed the association of common variants of UMOD with BP. The UMOD promoter common variant rs13333226 G/A is associated with diastolic BP (DBP), and G allele carriers have higher DBP compared with A/A homozygotes (P= 0.035). The variant rs6497476 C/T predicted the DBP level, with C homozygotes having a higher DBP compared with CT heterozygotes and T homozygotes (P= 0.025). Urinary UMOD excretion was correlated with urinary sodium excretion (R= 0.239, P= 0.656* 10− 13). We determined that common variants of UMOD are associated with DBP level in a community-based Chinese cohort.