Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease.
Supplementation with vitamin D and its analogs for treatment of endothelial dysfunction and cardiovascular disease.
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DOI：
10.1590/1677-5449.190150
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发表时间：
2020-07-06
影响因子：
--
通讯作者：
Barbosa RHA
中科院分区：
文献类型：
--
作者：
Cardoso FEL;Dos Santos LDCM;Tenório APO;Lopes MR;Barbosa RHA
维生素D（1，25-二羟基胆钙化醇）是一种激素原，引起了研究人员的兴趣，因为研究表明其作用不仅限于骨代谢。因此，本综述总结了最新的研究结果，并讨论了处方维生素D及其类似物治疗和预防心血管疾病和内皮功能障碍的有用性。本文对文献进行了叙述性综述，选择了2012年至2019年发表的文章。研究表明，维生素D3及其类似物对内皮功能有有益的影响，但这些结果是有争议的，因为更大样本和更长时间的研究发现，使用这些物质后，发病率和死亡率或心血管风险因素没有减少。鉴于目前的技术水平，补充维生素D或其类似物来治疗内皮功能障碍或心血管疾病还没有明确的科学依据。
Vitamin D (1,25-dihydroxycolecalciferol) is a prohormone that has attracted the interest of researchers since studies have shown that its effects are not restricted to bone metabolism. Thus, the present review summarizes the most recent findings and discusses the usefulness of prescribing vitamin D and its analogues for treatment and prevention of cardiovascular disorders and endothelial dysfunction. The paper constitutes a narrative review of the literature, selecting articles published from 2012 to 2019. Studies have shown that vitamin D3 and its analogues have beneficial effects on endothelial function, but these results are controversial, since research with larger samples and of longer duration found no reduction in morbidity and mortality or cardiovascular risk factors after use of these substances. Given the current state of the art, there is no clear scientific basis for supplementation with vitamin D or its analogues for treatment of endothelial dysfunction or cardiovascular disease.
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影响因子：
37.8
作者：
Wong, Michael Sze Ka;Leisegang, Matthias S.;Brandes, Ralf P.
通讯作者：
Brandes, Ralf P.
DOI：
10.1007/s12265-012-9436-x
发表时间：
2013-04-01
影响因子：
3.4
作者：
Polidoro, Lorella;Properzi, G.;Ferri, C.
通讯作者：
Ferri, C.
影响因子：
--
作者：
Neves JA;Neves JA;Oliveira RCM
通讯作者：
Oliveira RCM
影响因子：
3.7
作者：
Won S;Sayeed I;Peterson BL;Wali B;Kahn JS;Stein DG
通讯作者：
Stein DG
影响因子：
39.3
作者：
Dong, Jinghui;Wong, Siu Ling;Huang, Yu
通讯作者：
Huang, Yu