Natural anti-CCR5 antibodies in HIV-infection and -exposure.
Natural anti-CCR5 antibodies in HIV-infection and -exposure.
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DOI：
10.1186/1479-5876-9-s1-s4
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发表时间：
2011-01-27
影响因子：
7.4
通讯作者：
Lopalco L
中科院分区：
文献类型：
--
作者：
Lopalco L
天然抗体是抵御病原体的第一道防线；它们还可以通过结合宿主抗原、表面分子和受体，在免疫调节和动态平衡方面发挥其他作用。天然的抗CCR5抗体对预防粘膜组织中的艾滋病毒感染具有决定性作用，并仅在病毒进入的主要部位提供及时和有效的保护。在天然抗CCR5抗体中，针对ECL1结构域的Ig G和Ig A已被证明能有效和持久地阻断HIV，而不会对宿主造成伤害。将介绍和讨论它们的生物学特性以及它们在艾滋病毒感染者和艾滋病毒暴露者亚群(即所谓的ESN)中的罕见产生，目的是开发它们在治疗和预防方面的潜力。
Natural antibodies constitute a first-line of defence against pathogens; they may also play other roles in immune regulation and homeostasis, through their ability to bind host antigens, surface molecules and receptors. Natural anti-CCR5 antibodies can be decisive in preventing HIV infection in mucosal tissues and offer prompt and effective protection just at major sites of virus entry. Among natural anti-CCR5 antibodies, IgG and IgA to the ECL1 domain have been shown to block HIV effectively and durably without causing harm to the host. Their biological properties and their uncommon generation in subsets of HIV-infected and HIV-exposed individuals (so called ESN) will be introduced and discussed, with the aim at exploiting their potential in therapy and prevention.