Human endometrium: an active site of cytokine production and action.
Human endometrium: an active site of cytokine production and action.
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DOI：
10.1210/edrv-12-3-272
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发表时间：
1991-08
影响因子：
20.3
通讯作者：
S. Tabibzadeh
中科院分区：
文献类型：
--
作者：
S. Tabibzadeh
在人类子宫内膜中，由上皮细胞、间质细胞、内皮细胞和淋巴样细胞组成的细胞网络的复杂相互作用表现为增殖、分化和月经脱落的协调阶段。显然，这些动态的细胞间相互作用需要发展良好的细胞间通信信号阵列。人类子宫内膜的许多变化使人联想到与炎症和修复过程有关的变化。因此，新出现的证据表明促炎症细胞因子参与子宫内膜反应也就不足为奇了。细胞因子受体的表达，子宫内膜细胞产生这些因子，以及这些因子对子宫内膜功能的调节，都表明细胞因子可能在人类子宫内膜的自分泌、旁分泌和内分泌水平上起作用。在接下来的章节中，出现了细胞因子在人类子宫内膜中作用的新证据。在这个..。
I. Introduction Complex interactions of a network of cells comprised of epithelial, stromal, endothelial, and lymphoid cells in human endometrium are displayed as orchestrated phases of proliferation, differentiation, and menstrual shedding. It is clear that these dynamic cell-to-cell interactions require a well developed array of intercellular communication signals. Many of the changes that occur in human endometrium are reminiscent of those associated with the inflammatory and reparative processes. Thus, it is not surprising that emerging evidence suggests the involvement of proinflammatory cytokines in endometrial reactions. Expression of the receptors for cytokines, production of these factors by endometrial cells, and regulation of endometrial functions by these factors all indicate the potential of cytokines to serve at autocrine, paracrine, and endocrine levels in human endometrium. In the succeeding sections, the emerging evidence for the role of cytokines in human endometrium is presented. In thi...