Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.
Anemia induces accumulation of erythropoietin mRNA in the kidney and liver.
复制标题
贫血会导致促红细胞生成素 mRNA 在肾脏和肝脏中积聚。
DOI：
10.1128/mcb.6.7.2731-2733.1986
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发表时间：
1986
影响因子：
5.3
通讯作者：
Koury,MJ
中科院分区：
文献类型：
--
作者：
Bondurant,MC;Koury,MJ
红细胞生成素的产生的调节主要通过控制红细胞生成素mRNA的积累在肾脏和肝脏中发生。红细胞生成素mRNA在贫血后1.5小时首次在肾脏中检测到，并在4至8小时达到至少比对照值高200倍的平台值。报道的促红细胞生成素mRNA起始位点上游的20个碱基序列与18S rRNA中的高变序列互补。
Regulation of the production of erythropoietin occurs in the kidney and liver largely through control of accumulation of erythropoietin mRNA. Erythropoietin mRNA was first detected in kidneys at 1.5 h postanemia and reached a plateau value at least 200-fold above the control value by 4 to 8 h. A 20-base sequence immediately upstream from the reported erythropoietin mRNA initiation site is complementary to a hypervariable sequence in 18S rRNA.