Design of a G-Quadruplex Topology through Glycosidic Bond Angles
Design of a G-Quadruplex Topology through Glycosidic Bond Angles
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DOI：
10.1002/anie.200902454
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发表时间：
2009-01-01
影响因子：
16.6
通讯作者：
Plavec, Janez
中科院分区：
文献类型：
--
作者：
da Silva, Mateus Webba;Trajkovski, Marko;Plavec, Janez
为了实现 DNA 物体、设备和材料的程序化构建，构成装配过程控制基础的原理的系统化是必要的。迄今为止，命名为 G 四链体的四链 DNA 结构的发现要么是偶然的，要么是偶然出现的。在此，我们利用基于糖苷键角的两种状态配置的合理方法来设计G四链体。
To realize a programmed build up of DNA objects, devices, and materials, a systematization of the principles that formthe basis of control for the assembly process is necessary. Thusfar the discovery of four-stranded DNA architecturesdenominated G quadruplexes was either serendipitous orthrough coincidental emergence. Herein we utilize a rationalapproach for the design of G quadruplexes based on the twostatedisposition of the glycosidic bond angle.