Intrahepatic cholangiocarcinoma in the setting of HBV-related cirrhosis: Differentiation with hepatocellular carcinoma by using Intravoxel incoherent motion diffusion-weighted MR imaging.
Intrahepatic cholangiocarcinoma in the setting of HBV-related cirrhosis: Differentiation with hepatocellular carcinoma by using Intravoxel incoherent motion diffusion-weighted MR imaging.
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HBV 相关肝硬化背景下的肝内胆管癌：使用 Intravoxel 不相干运动扩散加权 MR 成像与肝细胞癌鉴别
DOI：
10.18632/oncotarget.23807
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发表时间：
2018-01-30
期刊：
影响因子：
--
通讯作者：
Song B
中科院分区：
文献类型：
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作者：
Wei Y;Gao F;Zheng D;Huang Z;Wang M;Hu F;Chen C;Duan T;Chen J;Cao L;Song B
术前准确鉴别肝内胆管细胞癌（ICC）和肝细胞癌（HCC）在急性肝硬化的背景下具有重要的临床意义，因为这些实体的治疗和预后显着不同。通过回顾性研究，我们试图确定体素内非相干运动（IVIM）和扩散加权成像（DWI）参数在ICC和HCC的鉴别诊断性能。结果表明，单指数模型的表观扩散系数（ADC）和双指数模型的真实ADC（ADCslow）均能区分ICC和HCC，且ADCslow的诊断性能优于ADC。然而，伪ADC值（ADC fast）和灌注分数（f）不能用来区分ICC和HCC。结果提示IVIM和DWI参数对ICC和HCC的鉴别诊断、治疗方案的选择和预后判断有一定的参考价值。
Accurate preoperative differentiation of intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) in the setting of cirrhotic liver is of great clinical significance because the treatment and prognosis of these entities differ markedly. Through a retrospectively research, we sought to determine the diagnostic performances of intravoxel incoherent motion (IVIM) and diffusion weighted imaging (DWI) parameters in the differentiating of ICC and HCC. According to the results, we found that apparent diffusion coefficient (ADC) derived from mono-exponential model and true ADC (ADCslow) derived from bi-exponential model can be used to distinguish the ICC and HCC, and ADCslowentailed the higher diagnostic performance than ADC. However, pseudo-ADC (ADCfast) and perfusion fraction (f) can not be used to differentiate ICC and HCC. These results suggested that IVIM and DWI parameters can be useful in differentiating ICC and HCC and might be helpful in selecting the treatment plan and predicting prognosis.