The Effect of the Infection Rate on Oncolytic Virotherapy
The Effect of the Infection Rate on Oncolytic Virotherapy
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DOI：
10.11648/j.cbb.20200801.14
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发表时间：
2020-07
期刊：
影响因子：
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通讯作者：
Dongwook Kim;Haeyoung Kim;Hui Wu;Dong-Hoon Shin
中科院分区：
文献类型：
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作者：
Dongwook Kim;Haeyoung Kim;Hui Wu;Dong-Hoon Shin
溶瘤病毒已成为各种癌症治疗的新工具。几种天然溶瘤病毒和工程溶瘤病毒被开发用于溶瘤病毒治疗。虽然我们在细胞水平上对病毒复制和病毒诱导的细胞裂解的分子机制有了很好的了解，但溶瘤病毒和癌细胞作为一个群体是如何相互作用的还不清楚。为了进一步了解溶瘤病毒与癌细胞之间的动态相互作用，已经建立了一些溶瘤病毒治疗的数学模型。许多作者研究了病毒复制对肿瘤细胞群动力学的影响，并提出病毒的爆发率是溶瘤病毒治疗成功的重要因素。在本研究中，我们研究了溶瘤病毒感染率对溶瘤病毒治疗模型的影响。重点研究了病毒爆发率和病毒感染率两个控制参数之间的关系，得到了从平衡稳态到周期解的模式。基于该模型，癌细胞与溶瘤病毒之间的相互作用表现出一个有趣的二维分岔，显示出三个参数区域（平衡稳态、阻尼振荡和振荡）。我们的结果表明，感染率和破裂率是溶瘤病毒设计成功的溶瘤病毒疗法的关键特性。
Oncolytic viruses have become a novel therapeutic tool for various cancer treatments. Several naturally occurring oncolytic viruses and engineered oncolytic viruses are developed for oncolytic virotherapies. Although we have a good understanding on molecular mechanisms of viral replication and virus-induced cell lysis at the cellular level, it is unclear how oncolytic viruses and cancer cells interact as a population. Several mathematical models of oncolytic virotherapy have been developed to advance the understanding of dynamic interaction between oncolytic viruses and cancer cells. Many authors investigated the effect of the virus replication on dynamics of cancer cell population and proposed that the bursting rate of viruses is an important factor for successful oncolytic virotherapy. In this study, we investigate the effect of infection rate of oncolytic viruses on an oncolytic virotherapy model. Particularly, we focused on studying the relationship between two control parameters, bursting rate and infection rate of the virus, to generate the patterns from equilibrium steady state to periodic solutions. Based on the model, the interaction between cancer cells and oncolytic viruses shows an intriguing two-dimensional bifurcation, showing three parameter regions (equilibrium steady state, damped oscillations and oscillations). Our result suggests that both infection rate and bursting rate are crucial properties of oncolytic viruses to design a successful oncolytic virotherapy.