Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin
Neonatal adiposity following maternal treatment of gestational diabetes with glyburide compared with insulin
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DOI：
10.1016/j.ajog.2009.02.038
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发表时间：
2009-05-01
影响因子：
9.8
通讯作者：
Jeyabalan, Arun
中科院分区：
文献类型：
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作者：
Lain, Kristine Y.;Garabedian, Matthew J.;Jeyabalan, Arun
目的：我们假设，身体成分将是相似的妊娠期糖尿病（GDM）与格列本脲或insulin.Study Design治疗的妇女之间的新生儿：GDM需要药物治疗的妇女被随机分配到胰岛素或格列本脲。主要结果是通过全身电导率测量的新生儿脂肪量百分比。次要结局包括人体测量学、血糖控制和生物标志物。统计学分析采用t检验、卡方检验和回归分析。各组的基线因素无差异。治疗组之间的新生儿脂肪量百分比无差异（11.2 +/- 4.2 vs 12.8 +/- 5.7）。按意向治疗组或实际治疗组分析时，脂肪量、体重指数、体重指数、皮褶总和和手臂脂肪面积无差异。脐带血中生物标志物的浓度也相似。结论：接受格列本脲或胰岛素治疗的GDM孕妇的新生儿肥胖率无差异。
OBJECTIVE: We hypothesized that body composition would be similar among neonates of women with gestational diabetes (GDM) treated with glyburide or insulin.STUDY DESIGN: Women with GDM requiring medical therapy were randomized to insulin or glyburide. The primary outcome was percent neonatal fat mass measured by total body electrical conductivity. Secondary outcomes included anthropometrics, glycemic control, and biomarkers. Statistical analysis included Student t test, chi(2), and regression modeling.RESULTS: Eighty-two neonates underwent postnatal measurements. Baseline factors were not different by group. Neonatal percent fat mass did not differ between treatment groups (11.2 +/- 4.2 vs 12.8 +/- 5.7). Fat mass, body mass index, ponderal index, skinfold sum, and arm fat area were not different when analyzed by intent to treat or actual treatment group. Cord concentrations of biomarkers were also similar.CONCLUSION: There was no difference in neonatal adiposity in infants of women treated for GDM with glyburide or insulin.