Oxidation of Anthranilic Acid by a Species of Achromobacter isolated from Soil
Oxidation of Anthranilic Acid by a Species of Achromobacter isolated from Soil
复制标题
从土壤中分离的无色杆菌对邻氨基苯甲酸的氧化
作者：
J. Ladd
微生物分解邻氨基苯酸的研究主要局限于通过未知途径将邻氨基苯酸氧化为儿茶酚的各种假单胞菌1 - 3菌株。水杨酸的作用报道以来,这种转换并不清楚实验技术的基础上,同时适应了不同其中回答,4。Sakamoto等人4进一步表明，适应于氧化邻氨基苯酸的细胞悬浮液对3-羟基邻氨基苯酸和5-羟基邻氨基苯酸无活性。相比之下，这两种后命名的化合物显然与哺乳动物组织对邻氨基苯酰胺的分解有关，因为它们都是从注射了邻氨基苯甲酸或邻氨基苯酰胺5 - 9的动物的尿液中分离出来的。
STUDIES of the microbial decomposition of anthranilic acid have been confined mostly to work with various strains of Pseudomonas spp.1–3 which oxidize anthranilic acid to catechol by an unknown pathway. The role of salicylic acid in this conversion is not clear since reported experiments based on the technique of simultaneous adaptation have yielded divergent results1,4. Sakamoto et al.4 have further shown that cell suspensions, adapted to oxidize anthranilic acid, are inactive towards 3-hydroxyanthranilic acid and 5-hydroxyanthranilic acid. By contrast, the two last-named compounds have been clearly implicated in the breakdown of anthranilic acid by mammalian tissue since both have been isolated from the urine of animals injected with anthranilic acid or o-aminobenzamide5–9.