Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer
Associations between a patient-reported outcome (PRO) measure of sarcopenia and falls, functional status, and physical performance in older patients with cancer
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DOI：
10.1016/j.jgo.2015.07.007
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发表时间：
2015-11-01
影响因子：
3
通讯作者：
Mohile, Supriya G.
中科院分区：
文献类型：
--
作者：
Gewandter, Jennifer S.;Dale, William;Mohile, Supriya G.
目的：在老年癌症患者中，我们旨在调查患者报告的肌少症结局指标 (SarcoPRO) 与短期体力表现评分 (SPPB)、自我报告的跌倒和工具性日常生活活动限制 (IADL) 之间的关联。材料和方法：对在老年专业肿瘤护理和研究 (SOCARE) 诊所就诊的老年、通常体弱的癌症患者进行初步评估，作为初始评估的一部分。使用 Spearman 相关性和 Wilcoxon 符号排序检验评估单变量关联。 Logistic 回归用于确定临床因素和 SarcoPRO 评分或 SPPB 评分与跌倒和 IADL 限制的关联。结果：总共对 174 名老年癌症患者进行了评估。 SarcoPRO 和 SPPB 之间存在中等相关性 (rho = 0.62)。调整多种临床因素后，SarcoPRO 和 SPPB 均与跌倒无关。相比之下，较高的 SarcoPRO（即更差）和较低的 SPPB（即更差）分数均与 IADL 的局限性相关（预测变量中一个单位变化的比值比：SarcoPRO：1.06，p < 0.0001；SPPB：0.71，p = 0.003）。使用 SarcoPRO 和 SPPB 的模型解释了与 IADL 限制相关的相似量的变异性（AUC：分别为 0.88 与 0.87）。 结论：SarcoPRO 与 SPPB（身体表现的客观指标）中度相关，并且与 IADL 限制相关。因此，出现 IADL 限制的老年癌症患者应筛查肌少症。 SarcoPRO 显示出作为肌肉减少症研究筛查和结果评估措施的前景。 (C) 2015 Elsevier Ltd. 保留所有权利。
Objective: In older patients with cancer, we aimed to investigate associations between a patient-reported outcome measure for sarcopenia (SarcoPRO) and the Short Physical Performance Battery (SPPB), self-reported falls, and limitations in instrumental activities of daily living (IADLs).Materials and Methods: Assessments were conducted as part of the initial evaluation of older, often frail, patients with cancer seen in the Specialized Oncology Care and Research in the Elderly (SOCARE) clinic. Univariate associations were evaluated using Spearman's correlation and Wilcoxon sign ranked tests. Logistic regressions were used to identify associations of clinical factors and SarcoPRO scores or SPPB scores with falls and IADL limitations.Results: In total, 174 older patients with cancer were evaluated. A moderate correlation was found between the SarcoPRO and the SPPB (rho = 0.62). After adjusting for multiple clinical factors, neither the SarcoPRO nor the SPPB were associated with falls. In contrast, both higher SarcoPRO (i.e., worse) and lower SPPB (i.e., worse) scores were associated with limitations in IADLs (odds ratio for one unit change in predictor: SarcoPRO: 1.06, p < 0.0001; SPPB: 0.71, p = 0.003, respectively). Models using the SarcoPRO and SPPB explained similar amounts of variability in association with IADL limitations (AUC: 0.88 vs. 0.87, respectively).Conclusions: The SarcoPRO was moderately associated with the SPPB, an objective measure of physical performance, and was associated with limitations in IADLs. Thus, older patients with cancer who present with IADL limitations should be screened for sarcopenia. The SarcoPRO shows promise as a measure for screening as well as outcome assessment for research on sarcopenia. (C) 2015 Elsevier Ltd. All rights reserved.