Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.
Pharmacologic interruption of the mitogen-activated extracellular-regulated kinase/mitogen-activated protein kinase signal transduction pathway: potential role in promoting cytotoxic drug action.
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发表时间：
2001-04
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通讯作者：
P. Dent;Steven Grant
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作者：
P. Dent;Steven Grant
在过去的十年中，人们对信号通路在控制肿瘤细胞行为中的作用的兴趣急剧增加。这种兴趣主要集中在MAPK[3][1]通路的成员，包括ERK、JNK（也称为SAPK）和p38激酶模块[[5]]。
Over the last 10 years, there has been a dramatic increase in interest in the role of signaling pathways in governing neoplastic cell behavior. Much of this interest has focused on members of the MAPK[3][1] pathways, which include the ERK, the JNK, also called the SAPK, and the p38 kinase modules [(