Bisphenol A and Related Compounds in Dental Materials
Bisphenol A and Related Compounds in Dental Materials
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DOI：
10.1542/peds.2009-2693
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发表时间：
2010-10-01
期刊：
影响因子：
8
通讯作者：
Landrigan, Philip J.
中科院分区：
文献类型：
--
作者：
Fleisch, Abby F.;Sheffield, Perry E.;Landrigan, Philip J.
背景：含有双酚A（BPA）衍生物的牙科密封剂和复合填充材料越来越多地用于儿童牙科。越来越多的证据表明，BPA和一些BPA衍生物可能会对健康造成风险，这归因于它们的内分泌干扰和雌激素特性。目的：系统地汇编和批判性地评价表征牙科材料中BPA含量的文献;评估牙科材料中BPA的暴露和潜在的健康风险;并制定循证指南，以减少BPA暴露，同时促进口腔健康。现存的毒理学文献和材料安全数据表被用作datasource.RESULTS：双酚A是从牙科树脂释放通过唾液酶水解的双酚A衍生物，和双酚A是可检测到的唾液中长达3小时后树脂放置。从现有数据中，全身吸收BPA的数量和持续时间尚不清楚。含有双酚A衍生物二甲基丙烯酸缩水甘油酯（bis-GMA）的牙科产品不太可能水解为BPA，并且比含有双酚A二甲基丙烯酸酯（bis-DMA）的牙科产品具有更低的雌激素活性。牙科材料中使用的大多数其他BPA衍生物尚未进行雌激素活性评价。BPA的暴露可以减少清洗和冲洗表面的密封剂和复合材料后立即placement.CONCLUSIONS：在树脂基牙科材料和BPA暴露的短暂性证明的好处的基础上，我们建议继续使用严格遵守预防应用技术。怀孕期间应尽可能减少使用这些材料。应要求制造商报告牙科产品化学成分的完整信息，并鼓励制造商开发雌激素可能性较小的材料。儿科2010;126：760-768
CONTEXT: Dental sealants and composite filling materials containing bisphenol A (BPA) derivatives are increasingly used in childhood dentistry. Evidence is accumulating that BPA and some BPA derivatives can pose health risks attributable to their endocrine-disrupting, estrogenic properties.OBJECTIVES: To systematically compile and critically evaluate the literature characterizing BPA content of dental materials; to assess BPA exposures from dental materials and potential health risks; and to develop evidence-based guidance for reducing BPA exposures while promoting oral health.METHODS: The extant toxicological literature and material safety data sheets were used as data sources.RESULTS: BPA is released from dental resins through salivary enzymatic hydrolysis of BPA derivatives, and BPA is detectable in saliva for up to 3 hours after resin placement. The quantity and duration of systemic BPA absorption is not clear from the available data. Dental products containing the bisphenol A derivative glycidyl dimethacrylate (bis-GMA) are less likely to be hydrolyzed to BPA and have less estrogenicity than those containing bisphenol A dimethacrylate (bis-DMA). Most other BPA derivatives used in dental materials have not been evaluated for estrogenicity. BPA exposure can be reduced by cleaning and rinsing surfaces of sealants and composites immediately after placement.CONCLUSIONS: On the basis of the proven benefits of resin-based dental materials and the brevity of BPA exposure, we recommend continued use with strict adherence to precautionary application techniques. Use of these materials should be minimized during pregnancy whenever possible. Manufacturers should be required to report complete information on the chemical composition of dental products and encouraged to develop materials with less estrogenic potential. Pediatrics 2010;126:760-768