Revision of the Thai Red Cross intradermal rabies post-exposure regimen by eliminating the 90-day booster injection
Revision of the Thai Red Cross intradermal rabies post-exposure regimen by eliminating the 90-day booster injection
复制标题
DOI：
10.1016/j.vaccine.2006.01.051
复制
发表时间：
2006-04-12
期刊：
影响因子：
5.5
通讯作者：
Sitprija, V
中科院分区：
文献类型：
--
作者：
Khawplod, P;Wilde, H;Sitprija, V
泰国红十字会皮内暴露后狂犬病预防方案（TRC-ID）正在泰国、菲律宾、斯里兰卡使用，并正在印度取得进展。它包括在第0、3、7天在两个部位皮内注射两次0.1 mL世界卫生组织推荐的任何组织培养狂犬病疫苗，然后在第28和90天注射一次。20年的经验表明，在接受TRC-ID方案的187，000名可能暴露于狂犬病的受试者中，约有11%没有返回接受90天的加强注射。然而，这一群体没有狂犬病死亡的报告。这刺激了两项研究，以确定是否可以取消90天的助推器。他们证明，如果在两个部位将单次28天0.1 mL注射增加到两次，则可以实现相当的抗体应答，并且可以省略90天加强注射。初步研究中使用的组织培养狂犬病疫苗为纯化鸡胚疫苗（PCEC Chiron），本研究中使用的是色谱纯化Vero细胞疫苗（CPRV，Aventis-Pasteur）。CPRV与纯化Vero细胞狂犬病疫苗（PVRV）具有相同的免疫原性和有效性。(c)2006爱思唯尔有限公司保留所有权利。
The Thai Red Cross intradermal post-exposure rabies prophylaxis regimen (TRC-ID) is being used in Thailand, the Philippines, Sri Lanka and is making inroads in India. It consists of two injections of 0.1 mL of any World Health Organization recommended tissue culture rabies vaccine intradermally at two sites on days 0, 3, 7, followed by one injection on days 28 and 90. Two decades of experience had shown that approximately 11% of 187,000 possibly rabies exposed subjects who received the TRC-ID schedule, did not return for the 90-day booster. No rabies deaths had, however, been reported from this group. This stimulated two studies to determine whether the 90-day booster can be abolished. They demonstrated that, if the single 28-day 0.1 mL injection is increased to two at two sites, a comparable antibody response can be achieved and the 90-day booster can be omitted. The tissue culture rabies vaccine used in the preliminary study was purified chick embryo vaccine (PCEC Chiron) and for this study it was chromatography purified Vero cell vaccine (CPRV, Aventis-Pasteur). CPRV had been previously shown to be as immunogenic and effective as purified Vero cell rabies vaccine (PVRV). (c) 2006 Elsevier Ltd. All rights reserved.