Reward timing in the primary visual cortex
Reward timing in the primary visual cortex
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DOI：
10.1126/science.1123513
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发表时间：
2006-03-17
期刊：
影响因子：
56.9
通讯作者：
Bear, MF
中科院分区：
文献类型：
--
作者：
Shuler, MG;Bear, MF
我们发现，当成年大鼠经历视觉刺激和随后的奖励之间的关联时，初级视觉皮质中相当大一部分神经元的反应从仅与刺激的物理属性有关的反应进化为准确预测奖励时间的反应。除了揭示成人V1反应的一种显著类型的可塑性外，这些数据还表明，奖励计时活动--一种“更高”的大脑功能--可以在感觉处理路径中很早就发生。这些发现挑战了对初级视觉皮质活动的传统解释。
We discovered that when adult rats experience an association between visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately predict the timing of reward. In addition to revealing a remarkable type of response plasticity in adult V1, these data demonstrate that reward-timing activity - a "higher" brain function - can occur very early in sensory-processing paths. These findings challenge the traditional interpretation of activity in the primary visual cortex.