COMPUTER-SIMULATION OF PROTEIN FOLDING
COMPUTER-SIMULATION OF PROTEIN FOLDING
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DOI：
10.1038/253694a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
WARSHEL, A
中科院分区：
文献类型：
--
作者：
LEVITT, M;WARSHEL, A
一个新的和非常简单的蛋白质构象的表示已被用来与能量最小化和热模拟蛋白质折叠。在一定条件下，该方法成功地将牛胰胰蛋白酶抑制剂从开链构象“复性”为接近天然分子的折叠构象。
A new and very simple representation of protein conformations has been used together with energy minimisation and thermalisation to simulate protein folding. Under certain conditions, the method succeeds in ‘renaturing’ bovine pancreatic trypsin inhibitor from an open-chain conformation into a folded conformation close to that of the native molecule.