Conformational Study of Catecholamines in Solution
Conformational Study of Catecholamines in Solution
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溶液中儿茶酚胺的构象研究
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
P. Solmajer
中科院分区：
文献类型：
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作者：
P. Solmajer
摘要用高分辨质子磁共振波谱法研究了去甲肾上腺素、多巴胺和麻黄碱在水溶液中的构象。我们发现，多巴胺的反式旋转异构体的摩尔分数增加，如果pH值从酸性变为碱性，而去甲肾上腺素和麻黄碱的相反的趋势是观察：侧链的左旋转异构体的形式变得更加人口。这些变化进行了讨论有关的苄型羟基的构象和/或结合到一个受体网站中的生物相的作用。
Abstract Conformations of noradrenaline, dopamine and ephedrine have been studied in aqueous solutions using high resolution PMR spectroscopy. We found that for dopamine the mole fraction of trans rotamer is increased if pH is changed from acidic to basic while for noradrenaline and ephedrine the opposite trend is observed: gauche rotamer forms of the side chain become more populated. These changes are discussed in relation to the role of the benzylic hydroxyl group for conformation and/or binding to a receptor site in the biophase.