Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers
Biodistribution properties of nanoparticles based on mixtures of PLGA with PLGA-PEG diblock copolymers
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DOI：
10.1016/j.ijpharm.2005.03.024
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发表时间：
2005-07-14
影响因子：
5.8
通讯作者：
Avgoustakis, K
中科院分区：
文献类型：
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作者：
Beletsi, A;Panagi, Z;Avgoustakis, K
研究了由聚乳酸-羟基乙酸共聚物（PLGA）和聚乳酸-羟基乙酸共聚物-聚乙二醇（PLGA-PEG）混合物制备的纳米粒的基本特性和生物分布特性。研究中包括相对低PEG含量的PLGA（45）-PEG（5）共聚物和相对高PEG含量的PLGA（5）-PEG（5）共聚物。增加PLGA/PLGA-PEG混合物的PLGA-PEG含量，或当PLGA（45）-PEG（5）被PLGA（5）-PEG（5）替代时，观察到纳米颗粒尺寸的减小和PEG从纳米颗粒损失的速率的增加。PLGA/PLGA（45）-PEG（5）纳米颗粒的血液停留随着其PLGA-PEG含量的增加而增加，在100%PLGA（45）-PEG（5）时达到最大血液寿命。相反，PLGA/PLGA（5）-PEG（5）纳米颗粒的血液滞留在80- 100%PLGA（5）-PEG（5）范围内表现出平台最大值。在PLGA-PEG比例低于80%时，PLGA/PLGA（45）-PEG（5）纳米颗粒表现出比PLGA/PLGA（5）-PEG（5）纳米颗粒更低的血液滞留，而在PLGA-PEG比例高于80%时，PLGA/PLGA（45）-PEG（5）纳米颗粒表现出比PLGA/PLGA（5）-PEG（5）纳米颗粒更高的血液滞留。这些发现表明，除了表面PEG含量外，PLGA/PLGA-PEG纳米颗粒的生物分布特性还受到纳米颗粒的尺寸和PEG从纳米颗粒中损失的速率的影响。(c)2005 Elsevier B. V.保留所有权利。
The basic characteristics and the biodistribution properties of nanoparticles prepared from mixtures of poly(lactide-co-glycolide) (PLGA) with poly(lactide-co-glycolide)-poly(ethylene glycol) (PLGA-PEG) copolymers were investigated. A PLGA(45)-PEG(5) copolymer of relatively low PEG content and a PLGA(5)-PEG(5) copolymer of relatively high PEG content were included in the study. Increasing the PLGA-PEG content of the PLGA/PLGA-PEG mixture, or when PLGA(45)-PEG(5) was replaced by PLGA(5)-PEG(5), a decrease in the size of the nanoparticles and an increase in the rate of PEG loss from the nanoparticles were observed. The blood residence of the PLGA/PLGA(45)-PEG(5) nanoparticles increased as their PLGA-PEG content was increased, reaching maximum blood longevity at 100% PLGA(45)-PEG(5). On the contrary, the blood residence of PLGA/PLGA(5)-PEG(5) nanoparticles exhibited a plateau maximum in the range of 80-100% PLGA(5)-PEG(5). At PLGA-PEG proportions lower than 80%, the PLGA/PLGA(45)-PEG(5) nanoparticles exhibited lower blood residence than the PLGA/PLGA(5)-PEG(5) nanoparticles, whereas at PLGA-PEG proportions higher than 80%, the PLGA/PLGA(45)-PEG(5) nanoparticles exhibited higher blood residence than the PLGA/PLGA(5)-PEG(5) nanoparticles. These findings indicate that apart from the surface PEG content, the biodistribution properties of the PLGA/PLGA-PEG nanoparticles are also influenced by the size of the nanoparticles and the rate of PEG loss from the nanoparticles. (c) 2005 Elsevier B.V. All rights reserved.