Field evaluation of the ICT malaria PF/PV immunochromatographic test for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand
Field evaluation of the ICT malaria PF/PV immunochromatographic test for the detection of asymptomatic malaria in a Plasmodium falciparum/vivax endemic area in Thailand
复制标题
DOI：
10.4269/ajtmh.2002.66.379
复制
发表时间：
2002-04-01
影响因子：
3.3
通讯作者：
Sattabongkot, J
中科院分区：
文献类型：
--
作者：
Coleman, RE;Maneechai, N;Sattabongkot, J
快速抗原测定为检测有症状患者的疟疾提供了有效的工具。然而，这些设备检测无症状疟疾的功效尚不明确，无症状疟疾的寄生虫水平通常显着低于有症状患者。我们在 2000 年 8 月至 12 月对泰国北碧府 Ban Kong Mong Tha 村进行的横断面疟疾调查中评估了新型恶性疟原虫-间日疟原虫联合免疫层析检测 (ICT Malaria Pf/Pv) 的功效。在研究过程中，共对 559 人进行了 1,976 次出血。厚血膜和薄血膜的盲法显微镜检查被用作所有不一致结果的金标准，并对 10% 一致的结果进行交叉检查。在测试的 1,976 个 ICT Malaria Pf/Pv 试纸中，98.3% (n = 1,943) 的表现符合预期，控制线的出现证明了这一点。 ICT Malaria Pf/Pv 测试对于诊断寄生虫血症大于或等于 500 个滋养体/μL 的恶性疟疾具有敏感性 (100.0%) 和特异性 (99.7%)；然而，只有 15.9% (13/82) 的感染者患有如此高的寄生虫血症率。当恶性疟原虫血症发生率
Rapid antigen assays provide an effective tool for the detection of malaria in symptomatic patients. However, the efficacy of these devices for detecting asymptomatic malaria, where parasite levels are normally significantly lower than in symptomatic patients, is less well established. We evaluated the efficacy of a new combined Plasmodium falciparum-Plasmodim vivax immunochromatographic test (ICT Malaria Pf/Pv) in a cross-sectional malaria survey of the village of Ban Kong Mong Tha, Kanchanaburi Provice, Thailand, from August to December 2000. A total of 1,976 bleeds were made from 559 individuals over the course of the study. Blinded microscopy of thick and thin blood films was used as the gold standards all discordant and 10% of concordant results were cross-checked. Of 1,976 ICT Malaria Pf/Pv dipsticks tested, 98.3% (n = 1,943) performed as expected, as evidenced by the appearance of the control line. The ICT Malaria Pf/Pv test was both sensitive (100.0%) and specific (99.7%) for the diagnosis of falciparum malaria with parasitemias of greater than or equal to500 trophozoites/muL; however only 15.9% (13/82) of infected individuals had parasitemia rates this high. When P. falciparum parasitemia rates were