Resumption of estrogen-induced gonadotropin surges in postpartum monkeys.
Resumption of estrogen-induced gonadotropin surges in postpartum monkeys.
复制标题
产后猴体内雌激素诱导的促性腺激素激增的恢复。
DOI：
10.1210/jcem-49-3-422
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发表时间：
1979
期刊：
影响因子：
--
通讯作者：
G. Hodgen
中科院分区：
文献类型：
--
作者：
R. Williams;D. Johnson;G. Hodgen
为了评估妊娠后猴子下丘脑-垂体（hp）系统的功能完整性，研究人员对产后（哺乳期和非哺乳期）和流产后（妊娠中期）雌性注射雌二醇苯甲酸酯（EB）后的外周血LH和FSH浓度进行了测定，该剂量的雌二醇苯甲酸酯（EB）已知能有效激发循环猴的促性腺激素激增。在一项对哺乳期和非哺乳期产后母亲以及流产后女性的纵向研究中，EB在产后1、3、5、7、9和11周连续给予。一些哺乳期的猴子在产后6个月还受到EB的挑战。在一项对哺乳期母亲的横断面研究中，在产后1、3、5、7和9周对EB的反应进行了评估。哺乳期猴子对EB的hp反应在产后180天内受到损害，因为雌激素治疗没有引起FSH或LH激增。相比之下，不哺乳的产后母亲和堕胎后的女性对这种积极反馈行为恢复了敏感性。
To evaluate the functional integrity of the hypothalamic-pituitary (H-P) system in postgestational monkeys, peripheral serum concentrations of LH and FSH were determined in postpartum (nursing and nonnursing) and postabortion (midpregnancy) females challenged with estradiol benzoate (EB) at a dose known to be effective in eliciting gonadotropin surges in cycling monkeys. In a longitudinal study of nursing and nonnursing postpartum mothers and postabortion females, EB was administered serially during weeks 1, 3, 5, 7, 9, and 11 post delivery. Some nursing monkeys were challenged with EB up to 6 months post partum. In a cross-sectional study of nursing mothers, this response to EB was evaluated during weeks 1, 3, 5, 7, and 9 postpartum. H-P responsivity to EB was impaired in nursing monkeys through 180 days post partum, in that FSH or LH surges were not induced by estrogen therapy. In contrast, nonnursing postpartum mothers and postabortion females regained their sensitivity to this positive feedback action...