The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life
The prevalence of chronic radiation enteritis following radiotherapy for cervical or endometrial cancer and its impact on quality of life
复制标题
DOI：
10.1016/j.ejon.2009.02.007
复制
发表时间：
2009-09-01
影响因子：
2.8
通讯作者：
Hackett, A.
中科院分区：
文献类型：
--
作者：
Abayomi, J.;Kirwan, J.;Hackett, A.
d 背景：研究表明 50% 的人可能患有慢性放射性肠炎 (CRE)（Andreyev, J., 2005. 盆腔放疗的胃肠道并发症：它们是否重要？ Gut 54, 1051-1054）。加米等人。 （Gami, B., Harrington, K., Blake, P., Dearnaley, D., Andreyev, H.J.N., 2003. 盆腔放疗后患者如何管理胃肠道症状。消化药理学和治疗学 18, 987-994）认为如果生活质量不受影响，这并不重要。本研究的目的是确定有多少女性在放疗后经历 CRE，并调查接受较高剂量放疗或处于晚期癌症的女性是否面临更高的风险。 方法：已完成宫颈癌或子宫内膜癌放疗的女性 (=117) 被要求填写一份经过验证的问卷，探讨肠道问题和生活质量。对回答进行评分并与已知大便失禁的女性的分数进行比较（Bugg, G.J., Kiff, E.S., Hosker, G., 2001。用于评估肛门失禁女性的新的与具体情况健康相关的生活质量调查问卷。英国妇产科杂志 108 (10). 1057-1067）。结果：使用分数‘0’到 表明没有症状，47% 的女性获得了 CRE 分数 (>0)，范围为 20-85（平均值 34，SD 14.4）。年轻女性 (p < 0.001) 和患有宫颈癌的女性 (p < 0.05) 更有可能获得 CRE 评分。未观察到评分与放疗剂量或癌症分期之间存在显着关系。结论：评分表明接受放疗的女性中约有一半会出现 CRE。由于缺乏 CRE 的警告信号，生活质量受到影响，特别是在疲劳和应对行为方面。 (C) 2009 Elsevier Ltd. 保留所有权利。
d Background: Studies suggest that 50% of people may suffer from chronic radiation enteritis (CRE) (Andreyev, J., 2005. Gastrointestinal complications of pelvic radiotherapy: are they of any importance? Gut 54, 1051-1054). Gami et al. (Gami, B., Harrington, K., Blake, P., Dearnaley, D., Andreyev, H.J.N., 2003. How patients manage gastrointestinal symptoms after pelvic radiotherapy. Alimentary Pharmacology and Therapeutics 18, 987-994) argue that this is unimportant if quality of life is unaffected. The aim of this study was to identify how many women experience CRE following radiotherapy and to investigate whether women who have higher doses of radiotherapy or more advanced stage of cancer are more at risk.Methods: Women (=117) who had completed radiotherapy for cervical or endometrial cancer were asked to complete a validated questionnaire exploring bowel problems and quality of life. Responses were scored and compared to scores for women with known faecal incontinence (Bugg, G.J., Kiff, E.S., Hosker, G., 2001. A new condition-specific health-related quality of life questionnaire for the assessment of women with anal incontinence. British journal of Obstetrics and Gynaecology 108 (10). 1057-1067).Results: Using a score of '0' to indicate no symptoms, 47% of women gained scores indicative of CRE (>0), range 20-85 (mean 34, SD 14.4). Younger women (p < 0.001) and women with cervical cancer (p < 0.05) were more likely to score for CRE. No significant relationship was observed between score and either radiotherapy dose or stage of cancer.Conclusions: Scoring suggests that about half of woman treated with radiotherapy develop CRE. Quality of life is affected, particularly regarding tiredness and coping behaviours due to lack of warning signs for CRE. (C) 2009 Elsevier Ltd. All rights reserved.