Cell non-autonomous regulation of health and longevity.
Cell non-autonomous regulation of health and longevity.
复制标题
细胞非自主性对健康与寿命的调控
DOI：
10.7554/elife.62659
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发表时间：
2020-12-10
期刊：
影响因子：
7.7
通讯作者：
Leiser SF
中科院分区：
文献类型：
--
作者：
Miller HA;Dean ES;Pletcher SD;Leiser SF
随着现代世界人口结构逐渐老龄化，在生物医学研究中，理解并缓解衰老的影响变得愈发重要。近期针对模式生物的研究表明，衰老过程常常会受到生物体感知和应对环境变化能力的影响。许多经过深入研究的影响衰老的途径都涉及感觉细胞，尤其是神经元，它们能向周围组织传递信号，并在面临压力时促进生存。重要的是，即使在没有压力的情况下，这些应激反应途径的激活往往也足以改善健康状况并延长寿命。在此，我们回顾了当前的研究现状，着重阐述从秀丽隐杆线虫到哺乳动物，细胞非自主性信号传导在调节衰老过程中的重要性。我们还将探讨一些新出现的概念，包括逆向信号传导、绘制这些网络的方法以及潜在治疗手段的开发。
As the demographics of the modern world skew older, understanding and mitigating the effects of aging is increasingly important within biomedical research. Recent studies in model organisms demonstrate that the aging process is frequently modified by an organism’s ability to perceive and respond to changes in its environment. Many well-studied pathways that influence aging involve sensory cells, frequently neurons, that signal to peripheral tissues and promote survival during the presence of stress. Importantly, this activation of stress response pathways is often sufficient to improve health and longevity even in the absence of stress. Here, we review the current landscape of research highlighting the importance of cell non-autonomous signaling in modulating aging from C. elegans to mammals. We also discuss emerging concepts including retrograde signaling, approaches to mapping these networks, and development of potential therapeutics.