The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD
The role of visceral and subcutaneous adipose tissue fatty acid composition in liver pathophysiology associated with NAFLD
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DOI：
10.4161/21623945.2014.978662
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发表时间：
2015-04-03
期刊：
影响因子：
3.3
通讯作者：
Foster, M. T.
中科院分区：
文献类型：
--
作者：
Gentile, C. L.;Weir, T. L.;Foster, M. T.
内脏肥胖与2型糖尿病、炎症、血脂异常和非酒精性脂肪性肝病（NAFLD）相关，而皮下肥胖与此无关。我们假设内脏肥胖和肝脏病理生理学之间的联系涉及内脏和皮下脂肪组织储存和动员饱和脂肪酸的固有或饮食来源的差异。本研究的目的是描述脂肪组织甘油三酯和门静脉脂肪酸的脂肪酸组成与肝脏失调指数的关系。在8周内，大鼠自由获得对照（CON; 12.9%玉米/红花油; 3.6 Kcal/g）、高饱和脂肪（SAT; 45.2%可可脂; 4.5 Kcal/g）或高多不饱和脂肪（PUFA; 45.2%红花油; 4.5 Kcal/g）饮食。结果指标包括葡萄糖耐量、内脏和皮下脂肪组织甘油三酯、肝脏磷脂和血浆（门静脉和全身）游离脂肪酸组成、肝脏和脂肪组织库中的炎症和内质网应激指数以及循环脂肪/细胞因子。与对照组相比，两个高脂饮食组的肝脏甘油三酯均显著增加，且PUFA显著高于SAT。虽然葡萄糖耐量在饮食组之间没有差异，但SAT增加了肝脏和两个脂肪组织库中的炎症和ER应激标志物。在任何饮食组中，脂肪库或门静脉血中的脂肪酸组成没有差异。总的来说，这些数据表明，富含饱和脂肪酸的饮食与肝脏炎症，ER应激和损伤有关，但内脏脂肪组织和这些肝脏指数之间的任何联系并不涉及该贮库或门静脉中脂肪酸组成的选择性变化。
Visceral adiposity is associated with type-2-diabetes, inflammation, dyslipidemia and non-alcoholic fatty liver disease (NAFLD), whereas subcutaneous adiposity is not. We hypothesized that the link between visceral adiposity and liver pathophysiology involves inherent or diet-derived differences between visceral and subcutaneous adipose tissue to store and mobilize saturated fatty acids. The goal of the present study was to characterize the fatty acid composition of adipose tissue triglyceride and portal vein fatty acids in relation to indices of liver dysregulation. For 8 weeks rats had free access to control (CON; 12.9% corn/safflower oil; 3.6 Kcal/g), high saturated fat (SAT; 45.2% cocoa butter; 4.5 Kcal/g) or high polyunsaturated fat (PUFA; 45.2% safflower oil; 4.5 Kcal/g) diets. Outcome measures included glucose tolerance, visceral and subcutaneous adipose tissue triglyceride, liver phospholipids and plasma (portal and systemic) free fatty acid composition, indices of inflammation and endoplasmic reticulum stress in the liver and adipose tissue depots and circulating adipo/cytokines. Hepatic triglycerides were significantly increased in both high fat diet groups compared to control and were significantly higher in PUFA compared to SAT. Although glucose tolerance was not different among diet groups, SAT increased markers of inflammation and ER stress in the liver and both adipose tissue depots. Fatty acid composition did not differ among adipose depots or portal blood in any dietary group. Overall, these data suggest that diets enriched in saturated fatty acids are associated with liver inflammation, ER stress and injury, but that any link between visceral adipose tissue and these liver indices does not involve selective changes to fatty acid composition in this depot or the portal vein.