Efferent and afferent connections of supratrigeminal neurons conveying orofacial muscle proprioception in rats
Efferent and afferent connections of supratrigeminal neurons conveying orofacial muscle proprioception in rats
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DOI：
10.1007/s00429-021-02391-9
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发表时间：
2021-10-05
影响因子：
3.1
通讯作者：
Inoue, Tomio
中科院分区：
文献类型：
--
作者：
Yoshida, Atsushi;Inoue, Misaki;Inoue, Tomio
三叉神经上核（Su 5）是控制下颌运动的关键结构;它接收来自下颌闭合肌梭（JCMSs）的本体感觉，并将投射发送到三叉神经运动核（Mo 5）。然而，JCMS本体感觉的中枢投射和调节尚未完全了解。因此，我们的目的是揭示Su 5的传出和传入连接使用神经束示踪。顺行示踪剂注射到Su 5显示Su 5发送对侧投射（或对侧优势的双侧投射）到Su 5、脑桥基底核、脑桥网状核、中脑深核、上级丘、丘脑腹后内侧核的尾侧-腹内侧边缘、丘脑束旁核、齿状回和外侧下丘脑，同侧（或同侧为主的双侧）投射至三叉神经间区、三叉神经口侧亚核、延髓背侧网状结构、舌下神经核和Mo 5。逆行示踪剂注入Su 5表明Su 5接受双侧投射，对侧占优势（或对侧投射）来自初级和次级躯体感觉皮质、颗粒岛皮质和Su 5，以及同侧投射（或同侧优势的双侧投射）来自背脚皮质，终纹床核，中央杏仁核，外侧下丘脑，丘脑旁核、三叉神经中脑核、臂旁核、三叉神经区、三叉神经口侧和尾侧亚核和背侧延髓网状结构。这些发现表明，接受JCMS本体感受的Su 5与参与情绪和自主神经功能以及口面运动功能的多个脑区具有传出和传入连接。
The supratrigeminal nucleus (Su5) is a key structure for controlling jaw movements; it receives proprioceptive sensation from jaw-closing muscle spindles (JCMSs) and sends projections to the trigeminal motor nucleus (Mo5). However, the central projections and regulation of JCMS proprioceptive sensation are not yet fully understood. Therefore, we aimed to reveal the efferent and afferent connections of the Su5 using neuronal tract tracings. Anterograde tracer injections into the Su5 revealed that the Su5 sends contralateral projections (or bilateral projections with a contralateral predominance) to the Su5, basilar pontine nuclei, pontine reticular nucleus, deep mesencephalic nucleus, superior colliculus, caudo-ventromedial edge of the ventral posteromedial thalamic nucleus, parafascicular thalamic nucleus, zona incerta, and lateral hypothalamus, and ipsilateral projections (or bilateral projections with an ipsilateral predominance) to the intertrigeminal region, trigeminal oral subnucleus, dorsal medullary reticular formation, and hypoglossal nucleus as well as the Mo5. Retrograde tracer injections into the Su5 demonstrated that the Su5 receives bilateral projections with a contralateral predominance (or contralateral projections) from the primary and secondary somatosensory cortices, granular insular cortex, and Su5, and ipsilateral projections (or bilateral projections with an ipsilateral predominance) from the dorsal peduncular cortex, bed nuclei of stria terminalis, central amygdaloid nucleus, lateral hypothalamus, parasubthalamic nucleus, trigeminal mesencephalic nucleus, parabrachial nucleus, juxtatrigeminal region, trigeminal oral and caudal subnuclei, and dorsal medullary reticular formation. These findings suggest that the Su5, which receives JCMS proprioception, has efferent and afferent connections with multiple brain regions that are involved in emotional and autonomic functions as well as orofacial motor functions.