Product-dependent anti-factor VIII antibodies.
Product-dependent anti-factor VIII antibodies.
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DOI：
10.1111/hae.12127
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发表时间：
2013-07
期刊：
影响因子：
--
通讯作者：
G Mann K
中科院分区：
文献类型：
--
作者：
Butenas S;Krudysz-Amblo J;Rivard GE;G Mann K
The development of anti-factor (F)VIII antibodies in hemophilia A (HA) subjects undergoing replacement therapy has been well-documented. The correlation between antibody development and the FVIII product used for replacement therapy remains a subject of discussion. To evaluate the presence of anti-FVIII antibodies toward three commercial rFVIII products in 34 HA subjects’ plasmas. Antibodies were quantitated by a Multiplex Fluorescence Immunoassay. All plasmas contained anti-FVIII antibodies at variable concentrations ranging from 50 nM to 570 μM. Eleven of 20 HA subjects treated with one (r)FVIII product contained inhibitory anti-FVIII antibodies (0.8–3584 BU). The inhibitory antibody titer and the molar concentrations of total antibody were mildly correlated (r2=0.6). Pronounced differences in antibody recognition with the three rFVIII products were observed. For the group treated with Product “A”, the titer toward this product was 2.4-fold higher than that observed with another full-length rFVIII-containing product (Product “B”) and almost 4-fold higher than that measured with a B domain-less rFVIII product (Product “C”). For the group of 14 HA subjects treated with FVIII other than Product “A”, only one showed higher antibody titer when measured with this product. Our data suggest that the development of anti-FVIII antibodies is biased toward the product used for treatment and that a significant fraction of antibodies bind to the B domain of FVIII.
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影响因子：
3.9
作者：
Chalmers, E. A.;Brown, S. A.;Young, D.
通讯作者：
Young, D.
影响因子：
6.5
作者：
Dazzi, F;Tison, T;Girolami, A
通讯作者：
Girolami, A
DOI：
10.1073/pnas.79.5.1648
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
FULCHER, CA;ZIMMERMAN, TS
通讯作者：
ZIMMERMAN, TS
影响因子：
6.7
作者：
Lebreton, Aurelien;Lapalud, Priscilla;Lavigne-Lissalde, Geraldine
通讯作者：
Lavigne-Lissalde, Geraldine
影响因子：
3.9
作者：
Astermark, J
通讯作者：
Astermark, J