Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images:: Considering the variability of the collateral sulcus
Volumetry of temporopolar, perirhinal, entorhinal and parahippocampal cortex from high-resolution MR images:: Considering the variability of the collateral sulcus
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DOI：
10.1093/cercor/12.12.1342
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发表时间：
2002-12-01
期刊：
影响因子：
3.7
通讯作者：
Evans, AC
中科院分区：
文献类型：
--
作者：
Pruessner, JC;Köhler, S;Evans, AC
临床和基础神经科学的研究人员经常利用磁共振成像（MRI）对人类内侧颞叶（MTL）的结构进行体积分析。在神经退行性疾病中，MTL结构的精确体积分析可以帮助鉴别诊断，并可用于指导早期治疗。此外，在功能神经成像中，准确的定位对于正确解释特定记忆功能的局灶性MTL激活至关重要。在目前可用的方案中，MTL结构的精确和一致的体积分析以多种方式受到损害。最重要的是，为了覆盖MTL的所有结构，研究人员目前被迫将来自不同实验室的针对不同结构的独立开发的分割协议联合收割机组合。这种方法限制了解剖精度，因为这些协议是基于不同的解剖指南和描述，不能很容易地整合。本文提出的分割方法旨在解决这个问题，提出了海马旁回（PHG）的所有主要结构的分割准则。它被直接开发以补充海马和杏仁核的体积方案（Pruessner等人，2000，Cereb Cortex 10：433-442），从而允许以综合和一致的方式对所有主要MTL结构进行体积评估。此外，它考虑到神经解剖学外观的侧副沟，提出了一种方法来纠正周围皮质的变化，这个沟的体积。使用40名健康正常对照受试者（20名男性和20名女性，年龄范围18-42岁）的MR图像验证该方案。内和interrater系数，连同所有PHG结构的体积的平均值，与年龄和性别的相关性，以及半球差异的测试。
Researchers in clinical and basic neuroscience frequently target structures of the human medial temporal lobe (MTL) for volumetric analysis with magnetic resonance imaging (MRI). In neurodegenerative diseases, a precise volumetric analysis of MTL structures can assist in differential diagnosis and can be used in guiding early treatment. Also, in functional neuroimaging, exact localization is crucial for the correct interpretation of focal MTL activations with respect to specific memory functions. In presently available protocols, precise and consistent volumetric analysis of MTL structures is compromised in numerous ways. Most importantly, in order to cover all structures of the MTL, the researcher is presently forced to combine independently developed segmentation protocols for different structures from different laboratories. This approach limits anatomical precision because these protocols are based on different anatomical guidelines and descriptions that cannot easily be integrated. The segmentation approach presented in this paper was designed to address this issue by presenting segmentation guidelines for all major structures of the parahippocampal gyrus (PHG). It was developed directly to complement a volumetric protocol for hippocampus and amygdala (Pruessner et al., 2000, Cereb Cortex 10:433-442), thus allowing volumetric assessment of all major MTL structures in an integrated and consistent manner. Furthermore, it takes into consideration the neuroanatomical appearance of the collateral sulcus by presenting a method to correct the volumes of the surrounding cortices for the variability of this sulcus. The protocol was validated using MR images of 40 healthy normal control subjects (20 men and 20 women, age range 18-42 years). Intra-and interrater coefficients are presented, together with mean values for the volumes of all PHG structures, correlations with age and sex, and tests for hemispheric differences.