EFFECTS OF ACCESS TO A RUNNING WHEEL ON FOOD, WATER AND ETHANOL INTAKE IN RATS BRED TO ACCEPT ETHANOL
EFFECTS OF ACCESS TO A RUNNING WHEEL ON FOOD, WATER AND ETHANOL INTAKE IN RATS BRED TO ACCEPT ETHANOL
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DOI：
10.1016/0376-8716(95)01162-5
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发表时间：
1995-11-01
影响因子：
4.2
通讯作者：
HARDWICK, WC
中科院分区：
文献类型：
--
作者：
MCMILLAN, DE;MCCLURE, GYH;HARDWICK, WC
将来自印第安纳州大学品系的大鼠分为两组，每组3只大鼠，所述大鼠被饲养以接受乙醇（P大鼠）和不接受乙醇（NP大鼠）。第一组P和NP大鼠每天24 h自由进食、饮水和5%（w/v）乙醇。当食物、饮水和乙醇摄入量稳定后，将转轮引入笼中。进入转轮减少乙醇的摄入量和增加水的摄入量在P大鼠。当转轮被锁定在适当的位置，乙醇摄入量增加的P大鼠，但当转轮再次解锁，乙醇摄入量没有减少。进入转轮不影响NP大鼠的食物，水或乙醇摄入量。引入转轮时乙醇摄入量的减少在暴露于5%乙醇和后来暴露于10%乙醇的第二组P大鼠中重复出现。这种遗传模型的酒精消耗量的运行轮的引入所产生的乙醇消耗量的减少是类似于以前报道的使用时间表诱导的烦渴，以诱导乙醇摄入量。
Rats from the University of Indiana lines bred to accept ethanol (P rats) and not to accept ethanol (NP rats) were divided into two groups of 3 rats per group. The first group of P and NP rats was given free access to food, water and 5% (w/v) ethanol 24 h a day, After food, water and ethanol intake stabilized, a running wheel was introduced into the cage. Access to the running wheel decreased ethanol intake and increased water intake in P rats. When the running wheel was locked in place, ethanol intake by P rats increased, but when the wheel was unlocked again, no decrease in ethanol intake occurred. Access to the running wheel did not affect food, water or ethanol intake in NP rats. The decrease in ethanol intake when the running wheel was introduced was replicated in the second group of P rats exposed to 5% ethanol and later to 10% ethanol. The decreases in ethanol consumption produced by the introduction of a running wheel for this genetic model of alcohol consumption are similar to those previously reported using schedule-induced polydipsia to induce ethanol intake.