Comparison of Clinical Features Between Coxsackievirus A2 and Enterovirus 71 During the Enterovirus Outbreak in Taiwan, 2008: A Children's Hospital Experience
Comparison of Clinical Features Between Coxsackievirus A2 and Enterovirus 71 During the Enterovirus Outbreak in Taiwan, 2008: A Children's Hospital Experience
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DOI：
10.1016/s1684-1182(10)60016-3
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发表时间：
2010-04-01
影响因子：
7.4
通讯作者：
Lin, Tzou-Yien
中科院分区：
文献类型：
--
作者：
Chen, Shih-Perng;Huang, Yhu-Chering;Lin, Tzou-Yien
背景/目的：柯萨奇病毒A2（考克斯A2）是2008年台湾肠道病毒爆发的主要血清型。然而，考克斯A2感染的详细临床特征尚未报道。在这项研究中，我们比较了考克斯A2和肠道病毒71（EV 71）在2008年台湾肠道病毒爆发的临床表现和流行病学。方法：共280例住院患者（97例培养证实EV 71感染和183例培养证实考克斯A2感染）在2008年长庚儿童医学中心参加了这项研究。结果：考克斯A2和EV 71血清型均在6月达到高峰，随后迅速下降。71%的患者年龄小于3岁。两组的男女比例相同，均为1.6：1。EV 71感染患者的住院时间显著延长（4.1 vs. 3.0天，p
BACKGROUND/PURPOSE: Coxsackievirus A2 (Cox A2) was the predominant serotype in the enterovirus outbreak in Taiwan, 2008. However, detailed clinical features of Cox A2 infection have not been reported. In this study, we compared Cox A2 with enterovirus 71 (EV71) in terms of clinical manifestation and epidemiology during the 2008 enterovirus outbreak in Taiwan.METHODS: A total of 280 hospitalized patients (97 with culture-proven EV71 infection and 183 with culture-proven Cox A2 infection) in 2008 at the Chang Gung Children's Medical Center were enrolled in this study. Epidemiologic data, clinical manifestations, and outcomes for these patients were collected and compared.RESULTS: Both Cox A2 and EV71 serotypes peaked in June and declined soon afterwards. Seventy-one percent of the patients were younger than 3 years of age. Both groups had the same male-to-female ratio of 1.6:1. Patients with EV71 infection had a significantly longer hospitalization period (4.1 vs. 3.0 days, p