Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice.
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DOI：
10.18632/oncotarget.11713
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发表时间：
2016-10-04
期刊：
影响因子：
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通讯作者：
Liu F
中科院分区：
文献类型：
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作者：
Liu Z;Kundu-Roy T;Matsuura I;Wang G;Lin Y;Lou YR;Barnard NJ;Wang XF;Huang MT;Suh N;Liu F
以前基于细胞培养和异种移植动物模型的研究表明，Smad3在肿瘤形成的早期阶段对乳腺癌具有肿瘤抑制作用。在这份报告中，我们发现化学致癌物DMBA(7，12-二甲基苯并[a]菲)在Smad3杂合小鼠中诱导乳腺肿瘤形成的频率显著高于Smad3野生型小鼠。这是第一个表明Smad3抑制小鼠模型中乳腺肿瘤形成的遗传证据。我们的发现支持Smad3在乳腺癌中具有重要的肿瘤抑制功能的观点。
Previous studies based on cell culture and xenograft animal models suggest that Smad3 has tumor suppressor function for breast cancer during early stages of tumorigenesis. In this report, we show that DMBA (7,12-dimethylbenz[a]anthracene), a chemical carcinogen, induces mammary tumor formation at a significantly higher frequency in the Smad3 heterozygous mice than in the Smad3 wild type mice. This is the first genetic evidence showing that Smad3 inhibits mammary tumor formation in a mouse model. Our findings support the notion that Smad3 has important tumor suppressor function for breast cancer.