MOLECULAR CHARACTERIZATION OF HUMAN CD94 - A TYPE-II MEMBRANE GLYCOPROTEIN RELATED TO THE C-TYPE LECTIN SUPERFAMILY
MOLECULAR CHARACTERIZATION OF HUMAN CD94 - A TYPE-II MEMBRANE GLYCOPROTEIN RELATED TO THE C-TYPE LECTIN SUPERFAMILY
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DOI：
10.1002/eji.1830250904
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发表时间：
1995-09-01
影响因子：
5.4
通讯作者：
LANIER, LL
中科院分区：
文献类型：
--
作者：
CHANG, CW;RODRIGUEZ, A;LANIER, LL
自然杀伤（NK）细胞优先表达C型凝集素超家族的若干基因，这些基因与NK细胞功能的调节有关。我们证明CD94是一种由C型凝集素超家族的一个独特基因编码的II型膜蛋白。虽然CD94与NK细胞相关的NKR - P1和NKG2 C型凝集素基因的同源性仅限于糖识别结构域中保守的结构基序，但所有这些基因都位于人类12号染色体上，这与小鼠6号染色体是同线的，NK复合体（NKR - P1和Ly - 49）的基因就位于此。CD94的一个意外特征是其基本没有细胞质结构域，这意味着与其他受体的结合可能对该分子的功能是必要的。
Natural killer (NK) cells preferentially express several genes of the C-type lectin superfamily which have been implicated in the regulation of NK cell function. We demonstrate that CD94 is a type II membrane protein encoded by a unique gene of the C-type lectin superfamily. While homology of CD94 with the NK cell-associated NKR-P1 and NKG2 C-type lectin genes is limited to the structural motifs conserved in the carbohydrate recognition domain, all of these genes are on human chromosome 12, the syntenic of mouse chromosome 6, where genes of the NK complex (NKR-P1 and Ly-49) are located. An unexpected feature of CD94 is the essential absence of a cytoplasmic domain, implying that association with other receptors may be necessary for the function of this molecule.