Stem Cell-Derived Vascular Endothelial Cells and Their Potential Application in Regenerative Medicine
Stem Cell-Derived Vascular Endothelial Cells and Their Potential Application in Regenerative Medicine
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DOI：
10.1159/000331423
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发表时间：
2012-01-01
影响因子：
2.7
通讯作者：
Hirschi, Karen K.
中科院分区：
文献类型：
--
作者：
Chaudhury, Hera;Raborn, Eric;Hirschi, Karen K.
尽管尚未鉴定或产生血管干细胞群体，但血管内皮细胞和壁细胞(平滑肌细胞和周细胞)可以从目前已知的多潜能干细胞来源中获得，包括人类胚胎干细胞和诱导的多潜能干细胞。我们回顾了这些人类多能干细胞的血管潜能，它们被诱导分化为血管内皮细胞命运的机制，以及它们在再生医学中的应用。版权所有(C)2011 S.Karger AG，巴塞尔
Although a 'vascular stem cell' population has not been identified or generated, vascular endothelial and mural cells (smooth muscle cells and pericytes) can be derived from currently known pluripotent stem cell sources including human embryonic stem cells and induced pluripotent stem cells. We review the vascular potential of these human pluripotent stem cells, the mechanisms by which they are induced to differentiate toward a vascular endothelial cell fate, and their applications in regenerative medicine. Copyright (C) 2011 S. Karger AG, Basel