Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell.
Metabolic alterations produced in the liver by chronic ethanol administration. Changes related to energetic parameters of the cell.
复制标题
长期服用乙醇会导致肝脏代谢发生变化。
作者：
J. Bernstein;L. Videla;Y. Israel
1.大鼠长期服用乙醇21-27天后，肝脏切片中测得的O（2）消耗率增加。通过抑制Na（+）和K（+）的主动转运，可以消除额外的呼吸作用。二硝基苯酚仅在存在哇巴因的情况下激活给药动物肝脏中的呼吸速率。2.乙醇处理的动物肝脏中（86）Rb和（Na（+）+K（+））刺激的腺苷三磷酸酶活性的主动（哇巴因敏感）转运增加。3.慢性乙醇给药还导致肝细胞中磷酸化电位（[ATP]/[ADP][P（i）]）降低，这是由于[ATP]降低和[P（i）]升高。4.有人建议，增加钠泵活性是负责增加氧化能力和观察到的乙醇处理的动物的肝脏中的二硝基苯酚的不敏感性。
1. Chronic ethanol administration to rats for 21-27 days increases the rate of O(2) consumption as measured in liver slices. The extra respiration can be abolished by inhibition of the active transport of Na(+) and K(+). Dinitrophenol activates the respiratory rate in the liver of the treated animals only in the presence of ouabain. 2. Active (ouabain-sensitive) transport of (86)Rb and (Na(+)+K(+))-stimulated adenosine triphosphatase activity were increased in the livers of the ethanol-treated animals. 3. Chronic ethanol administration also led to a decrease in the phosphorylation potential ([ATP]/[ADP][P(i)]) in the liver cell owing to a decrease in [ATP] and an increase in [P(i)]. 4. It is suggested that an increased sodium pump activity is responsible for the increased oxidative capacity and for the insensitivity to dinitrophenol observed in the livers of ethanol-treated animals.