Repetition Probability Effects Depend on Prior Experiences
Repetition Probability Effects Depend on Prior Experiences
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DOI：
10.1523/jneurosci.5326-13.2014
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发表时间：
2014-05-07
影响因子：
5.3
通讯作者：
Kovacs, Gyula
中科院分区：
文献类型：
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作者：
Grotheer, Mareike;Kovacs, Gyula
梭形面部区域中的重复抑制（RS）的幅度受到面部重复概率的影响（萨默菲尔德等人，2008），这意味着知觉期望影响重复相关的过程。然而，令人惊讶的是，猕猴单细胞（Kaliukhovich和Vogels，2011）和人fMRI（Kovacs等人，2013）的研究没有发现重复概率[ P（rep）]调制的RS与非面部刺激在枕颞叶皮层，这表明效果是面部特异性的。这种类别选择性的一个可能解释是，人类对面孔的广泛经验会特别影响RS的神经机制，产生P（rep）调节效应。为了解决这个问题，我们使用fMRI来测试另一个训练有素的刺激类别的P（rep）效应，罗马字母表的直立字母以及不熟悉的错误字体。我们观察到显着的RS两个刺激集的字母形式区，以及在caudodorthoral部分的枕叶外侧复合体。有趣的是，P（rep）对RS的影响依赖于刺激：虽然我们观察到P（rep）调制的罗马字母，没有这样的效果被发现为不熟悉的错误字体在这两个领域。我们的研究结果表明，P（REP）RS的影响是明显的非面部刺激，以及，但它们取决于受试者的经验与刺激类别。这表明，第一次，先前的经验影响的影响，上下文预测信息的RS在人类枕颞叶皮层。
The magnitude of repetition suppression (RS) in the Fusiform Face Area is influenced by the probability of repetitions of faces (Summerfield et al., 2008), implying that perceptual expectations affect repetition-related processes. Surprisingly, however, macaque single-cell (Kaliukhovich and Vogels, 2011) and human fMRI (Kovacs et al., 2013) studies have failed to find repetition probability [ P(rep)] modulations of RS with nonface stimuli in the occipitotemporal cortex, suggesting that the effect is face specific. One possible explanation of this category selectivity is that the extensive experience humans have with faces affects the neural mechanisms of RS specifically, creating P(rep) modulatory effects. To address this question, we used fMRI to test the P(rep) effects for another well trained stimulus category, upright letters of the roman alphabet as well as for unfamiliar false fonts. We observed significant RS for both stimulus sets in the Letter Form Area as well as in the caudodorsal part of the lateral occipital complex. Interestingly, the influence of P(rep) on RS was dependent on the stimulus: while we observed P(rep) modulations for the roman letters, no such effects were found for the unfamiliar false fonts in either area. Our findings suggest that P(rep) effects on RS are manifest for nonface stimuli as well, but that they depend on the experience of the subjects with the stimulus category. This shows, for the first time, that prior experience affects the influence of contextual predictive information on RS in the human occipitotemporal cortex.