Circadian rhythm disorders.
Circadian rhythm disorders.
复制标题
昼夜节律紊乱。
DOI：
10.1055/s-2004-835063
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Zee,PhyllisC
中科院分区：
文献类型：
--
作者：
Reid,KathrynJ;Zee,PhyllisC
当个体试图在错误的昼夜节律时间睡觉时，就会发生昼夜节律睡眠障碍。内部昼夜节律计时系统与外部环境之间的不对准通常是由于昼夜节律计时系统功能的改变(例如，延迟或提前睡眠相综合症)或外部环境的改变(例如，时差)。然而，大多数昼夜节律睡眠障碍的临床表现受到生理、行为和环境因素的综合影响。这些疾病导致人们抱怨失眠和白天过度嗜睡，并在重要的功能和生活质量方面受到损害。目前的治疗主要涉及使用昼夜同步剂，如光，以重新调整内部和外部环境。这些治疗受到足够的诊断工具和良好控制的临床试验的限制。需要更好地了解这些疾病的病理生理学，才能开发出更有效的治疗方法。
Circadian rhythm sleep disorders occur when individuals attempt to sleep at the wrong circadian time. The misalignment between the internal circadian timing system and the external environment is typically due to either an alteration in the functioning of the circadian timing system (eg, delayed or advanced sleep phase syndrome) or to changes in the external environment (eg, jet lag). However, the clinical presentation of most of the circadian rhythm sleep disorders is influenced by a combination of physiological, behavioral, and environmental factors. These disorders lead to complaints of insomnia and excessive daytime sleepiness, with impairment in important areas of functioning and quality of life. Current treatments primarily involve the use of circadian synchronizing agents, such as light, to realign the internal and external environment. These treatments are limited by the availability of adequate diagnostic tools and well-controlled clinical trials. A better understanding of the pathophysiology of these disorders is required to develop more effective treatments.