Mediators of Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)
Mediators of Low-Grade Chronic Inflammation in Polycystic Ovary Syndrome (PCOS)
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DOI：
10.2174/1381612811319320012
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发表时间：
2013-10-01
影响因子：
3.1
通讯作者：
Escobar-Morreale, Hector F.
中科院分区：
文献类型：
--
作者：
Ojeda-Ojeda, Miriam;Murri, Mora;Escobar-Morreale, Hector F.
慢性低度亚临床炎症已越来越被认为是多囊卵巢综合征（PCOS）特征性内分泌、代谢和生殖障碍的中介因素。腹部肥胖和肥胖常出现在PCOS中。越来越多的证据表明，脂肪组织参与先天性和适应性免疫反应。炎症介质如细胞因子、急性时相蛋白和脂肪因子的持续释放使PCOS女性肥胖相关的炎症状态持续存在，可能导致胰岛素抵抗和其他长期心脏代谢危险因素。编码炎症相关介质的基因的遗传变异是PCOS发展的基础，它们与环境因素的相互作用可能导致这种综合征的异质性临床表型。在未来，改善炎症的策略可能被证明对PCOS和相关疾病的管理有用。
Chronic low-grade subclinical inflammation has been increasingly recognized as an interposer in the endocrine, metabolic and reproductive disturbances that characterize the polycystic ovary syndrome (PCOS). Abdominal adiposity and obesity are often present in PCOS. Mounting evidence indicates that adipose tissue is involved in innate and adaptive immune responses. Continuous release of inflammatory mediators such as cytokines, acute phase proteins, and adipokines perpetuates the inflammatory condition associated with obesity in women with PCOS, possibly contributing to insulin resistance and other long-term cardiometabolic risk factors. Genetic variants in the genes encoding inflammation-related mediators underlie the development of PCOS and their interaction with environmental factors may contribute to the heterogeneous clinical phenotype of this syndrome. In the future, strategies ameliorating inflammation may prove useful for the management of PCOS and associated conditions.