Mrp3, a mitogen-regulated protein/proliferin gene expressed in wound healing and in hair follicles
Mrp3, a mitogen-regulated protein/proliferin gene expressed in wound healing and in hair follicles
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DOI：
10.1210/endo.142.5.8132
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发表时间：
2001-05-01
期刊：
影响因子：
4.8
通讯作者：
Nilsen-Hamilton, M
中科院分区：
文献类型：
--
作者：
Fassett, JT;Nilsen-Hamilton, M
在皮肤伤口愈合期间，生长因子的局部表达的显著增加导致负责组织修复的细胞的迁移和增殖增加。有丝分裂原调节蛋白（mitogen-regulated protein，MRP）/增殖素（proliferin）是一类生长因子和血管生成因子。在这里，它表明，Mrp 3诱导伤口边缘角质形成细胞在皮肤伤口愈合过程中，也暂时出现在毛囊的外根鞘在毛发生长周期的后期阶段。在培养的角质形成细胞中，Mrp 3由角质形成细胞生长因子诱导，但不受表皮生长因子或转化生长因子α型诱导。在巨细胞病毒立即早期增强子和Mrp 3侧翼序列的联合控制下表达lacZ的转基因小鼠表现出创伤和毛发周期诱导的转基因表达。这些结果表明，Mrp 3基因的侧翼调控序列内的元件参与响应于这些事件的Mrp 3的激活。本文报道的结果表明，MRP 3可能作为生长因子和/或血管生成因子参与伤口愈合和毛囊周期。
During cutaneous wound healing, a marked increase in the local expression of growth factors results in increased migration and proliferation of the cells responsible for tissue repair. The mitogen-regulated protein (MRP)/proliferin proteins are growth factors and angiogenesis factors. Here it is demonstrated that Mrp3 is induced in wound edge keratinocytes during cutaneous wound healing and also temporally appears in the outer root sheath of the hair follicle during the late anagen phase of the hair cycle. In cultured keratinocytes, Mrp3 is induced by keratinocyte growth factor, but not by epidermal growth factor or by transforming growth factor type alpha. Transgenic mice, expressing lacZ under the combined control of the cytomegalovirus immediate early enhancer and the Mrp3 flanking sequences, demonstrate wound- and hair cycle-induced transgene expression. These results show that elements within the flanking regulatory sequences of the Mrp3 gene are involved in the activation of Mrp3 in response to these events. The results reported here suggest that MRP3 may participate in wound healing and hair follicle cycle as a growth factor and/or angiogenesis factor.