Investigation of specificity of auricular acupuncture points in regulation of autonomic function in anesthetized rats
Investigation of specificity of auricular acupuncture points in regulation of autonomic function in anesthetized rats
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DOI：
10.1016/j.autneu.2007.10.003
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发表时间：
2008-02-29
影响因子：
2.7
通讯作者：
Zhang, Hong-Qi
中科院分区：
文献类型：
--
作者：
Gao, Xin-Yan;Zhang, Shi-Ping;Zhang, Hong-Qi
耳针在临床上已被用于治疗各种植物神经紊乱。理论上，不同的耳区对自主神经功能有不同的影响。本研究旨在观察针刺不同耳区对心血管和胃反应的影响。在戊巴比妥钠麻醉的雄性Sprague-Dawley大鼠上，观察了耳轮尖（A（1））、耳轮中部（A（2））、耳轮尾部（A（3））、下耳甲（A（4））和对耳轮中部（A（5））5个耳轮区，分别用手针和不同参数电针刺激。用MA从A（1）、A（3）和A（4）诱发轻度降压反应（较基线降低6%-12%），用EA（100 Hz-1 mA）从所有五个区域诱发轻度降压反应。最大的降压反应（-18.4 +/-3.1mmHg，p < 0.001）由A（4）诱发。MA从A（4）和EA在A（3），A（4）和A（5）诱发小的心动过缓。A（1）、A（3）、A（4）的MA和A（2）的EA均可引起胃内压升高（8-14 mmH（2）O）。目前的研究结果不支持耳内高度特异性功能图的理论。相反，有一个类似的模式，自主神经的变化，以响应耳针，不同的强度取决于刺激的区域。(c)2007 Elsevier B. V.保留所有权利。
Auricular acupuncture has been used for various autonomic disorders in clinical practice. It has been theorized that different auricular areas have distinct influence on autonomic functions. The present study aims to examine the effects of acupuncture stimulation at different auricular areas on cardiovascular and gastric responses. In male Sprague-Dawley rats anesthetized with pentobarbital sodium, five auricular areas, which were located at the apex of the helix (A(1)), the middle of the helix (A(2)), the tail of the helix (A(3)) the inferior concha (A(4)) and the middle of the antihelix (A(5)), had been selected for stimulation with manual acupuncture (MA) and different parameters of electroacupuncture (EA). A mild depressor response (6%-12% decrease from baseline) was evoked from A(1), A(3) and A(4) by MA and from all five areas by EA (100 Hz-1 mA). The biggest depressor response (-18.4 +/- 3.1 mmHg, p < 0.001) was evoked from A(4). A small bradycardia was evoked by MA from A(4) and by EA at A(3), A(4) and A(5). Increase in intragastric pressure (8-14 mmH(2)O) was evoked by MA from A(1), A(3) and A(4) and by EA at A(2) These results show that similar patterns of cardiovascular and gastric responses could be evoked by stimulation of different areas of the auricle. The present results do not support the theory of a highly specific functional map in the ear. Rather, there is a similar pattern of autonomic changes in response to auricular acupuncture, with variable intensity depending on the area of stimulation. (c) 2007 Elsevier B.V. All rights reserved.