Genetics of coronary artery disease.
Genetics of coronary artery disease.
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DOI：
10.1161/circulationaha.113.005350
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发表时间：
2013-09-03
期刊：
影响因子：
37.8
通讯作者：
Vasan RS
中科院分区：
文献类型：
--
作者：
Lieb W;Vasan RS
在美国，冠心病影响1540万人1，并且是死亡和发病的主要原因之一。1家族性成分有助于心血管疾病（CVD）的易感性，2但直到全基因组关联研究（GWAS）的出现，才发现遗传位点在多个队列中与冠状动脉疾病（CAD）表现出一致的相关性。本文介绍了CAD的遗传基础的理解的最新进展。
Coronary heart disease affects≈ 15.4 million individuals in the United States1 and is one of the main causes of mortality and morbidity. 1 A familial component contributes to cardiovascular disease (CVD) susceptibility, 2 but it was not until the emergence of genomewide association studies (GWAS) that genetic loci were identified that displayed consistent associations with coronary artery disease (CAD) across multiple cohorts. The present article describes recent advances in the understanding of the genetic basis of CAD.