Diverse and potent activities of HGF/SF in skin wound repair
Diverse and potent activities of HGF/SF in skin wound repair
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DOI：
10.1002/path.1578
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发表时间：
2004-07-01
影响因子：
7.3
通讯作者：
Warn, R
中科院分区：
文献类型：
--
作者：
Bevan, D;Gherardi, E;Warn, R
在小鼠中进行的遗传研究突出了几种生长因子在皮肤修复中的重要作用，并为它们在治疗中的应用提供了理论基础。目前的研究表明，纤溶酶原相关生长因子HGF/SF（肝细胞生长因子/分散因子）促进伤口修复纯合子糖尿病db/db小鼠通过招募中性粒细胞，单核细胞和肥大细胞的伤口;通过促进内皮细胞迁移到受伤的区域;并通过增强角质形成细胞的迁移和增殖。结果，肉芽组织形成、伤口血管生成和上皮再生都增加。结果表明，HGF/SF影响并维持负责伤口修复的所有关键细胞过程，并指出这种分子用于治疗慢性皮肤伤口的独特潜力。版权所有（C）2004大不列颠和爱尔兰病理学会。出版社：John Wiley Sons，Ltd
Genetic studies in the mouse have highlighted essential roles for several growth factors in skin repair and have offered a rationale for their use in therapy. The present study shows that the plasminogen-related growth factor HGF/SF (hepatocyte growth factor/scatter factor) promotes wound repair in homozygous diabetic db/db mice by recruiting neutrophils, monocytes, and mast cells to the wound; by promoting the migration of endothelial cells to the injured area; and by enhancing keratinocyte migration and proliferation. As a result, granulation tissue formation, wound angiogenesis, and re-epithelialization are all increased. The results demonstrate that HGF/SF affects and sustains all key cellular processes responsible for wound repair and point to a unique potential of this molecule for the therapy of chronic skin wounds. Copyright (C) 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley Sons, Ltd.