The contents of high‐energy phosphates in different fibre types in skeletal muscles from rat, guinea‐pig and man.
The contents of high‐energy phosphates in different fibre types in skeletal muscles from rat, guinea‐pig and man.
复制标题
大鼠、豚鼠和人骨骼肌不同纤维类型中高能磷酸盐的含量。
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
Sjoholm
中科院分区：
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作者：
BY Lars Edstrom;Eric Hultman;Kent Sahlin;Hans;Sjoholm
1.在大鼠、豚鼠和人的不同纤维类型组成的骨骼肌中测量了静息状态下高能磷酸盐的含量。所有进行生物化学研究的肌肉都进行了组织化学表征。2.快缩肌的ATP/ADP比值高于慢缩肌，并且除了大鼠的舌头外，ATP和磷酸肌酸的含量也较高。3.磷酸肌酸的含量和琥珀酰脱氢酶的活性呈负相关，琥珀酰脱氢酶是氧化能力的标志酶。4.生物化学和组织化学数据与不同肌纤维类型的已知形态和功能特性相关。可以得出结论，快缩纤维具有高ATP/ADP比率，有利于能量产生的快速加速。磷酸肌酸的含量似乎与糖酵解能力有关，而与收缩时间无关。除了作为一种直接的能量来源，磷酸肌酸还可以作为乳酸酸中毒的缓冲剂。
1. The contents of high‐energy phosphates at rest have been measured in skeletal muscles with different fibre‐type composition from rat, guinea‐pig and man. All muscles studied biochemically have been characterized histochemically. 2. Fast‐twitch muscles had a higher ATP/ADP ratio than slow‐twitch muscles and, with the exception of the tongue in the rat, higher contents of ATP and phosphocreatine. 3. There was an inverse relationship between the content of phosphocreatine and the stainability for succinyl dehydrogenase, which is a marker enzyme for oxidative capacity. 4. The biochemical and histochemical data are discussed in relation to known morphological and functional properties of the different muscle‐fibre types. It is concluded that fast‐twitch fibres have a high ATP/ADP ratio favouring a fast acceleration of energy production. The content of phosphocreatine seems to be related to the glycolytic capacity but not to the contraction time. In addition to being an immediate energy source, phosphocreatine functions as a buffer against lactic acidosis.